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| Main Authors: | , |
|---|---|
| Format: | Recurso digital |
| Language: | English |
| Published: |
Zenodo
2026
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| Subjects: | |
| Online Access: | https://doi.org/10.5281/zenodo.20205823 |
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Table of Contents:
- <p class="p1">Agnimandya is considered a primary initiating factor in the formation of Ama, a metabolically immature and</p> <p class="p1">obstructive pathological entity described in Ayurveda. Although classical texts extensively discuss Agni and Ama,</p> <p class="p1">their pathophysiological correlation requires systematic reinterpretation in the context of diagnostic reasoning and</p> <p class="p1">staged therapeutic correction. To analyze the pathophysiological basis of Ama formation due to Agnimandya and to</p> <p class="p1">examine its diagnostic and therapeutic implications within a structured clinical framework. A conceptual analytical</p> <p class="p1">study was undertaken based on classical Ayurvedic sources, including Charaka Samhita, Sushruta Samhita, and</p> <p class="p1">Ashtanga Hridaya. Descriptions of Agni, Agnimandya, Ama, Srotorodha, and Sama–Nirama avastha were critically</p> <p class="p1">examined and synthesized. Therapeutic principles of staged Agni correction were interpreted in relation to the</p> <p class="p1">pathophysiological sequence. Impairment of Pachaka Pitta leads to Mandagni, resulting in incomplete digestion</p> <p class="p1">(Ajirna) and formation of immature metabolic intermediates. Persistent metabolic insufficiency culminates in Ama,</p> <p class="p1">which induces Srotorodha and promotes Sama Dosha, ultimately leading to systemic dysfunction. The cyclical</p> <p class="p1">suppression between accumulated Ama and weakened Agni explains chronicity and relapse. A graded therapeutic</p> <p class="p1">framework consisting of Agnisandhukshana, Agnidhaapana, and Agnisthirikarana provides a rational approach for</p> <p class="p1">metabolic restoration and long-term stabilization. Agnimandya-induced Ama formation represents a functional</p> <p class="p1">metabolic disturbance that precedes structural pathology. Early recognition of Sama states and stage-wise correction </p> <p class="p1">of Agni enhance diagnostic precision and therapeutic sustainability. The classical model offers a coherent metabolic</p> <p class="p1">framework with potential relevance for contemporary integrative research.</p> <p class="p1"><strong>Keywords:</strong> Agnimandya, Ama, Agni, Srotorodha, Ayurvedic pathophysiology</p>