Gorde:
| Egile Nagusiak: | , , , , , , , , , , |
|---|---|
| Formatua: | Recurso digital |
| Hizkuntza: | |
| Argitaratua: |
Zenodo
2026
|
| Gaiak: | |
| Sarrera elektronikoa: | https://doi.org/10.5281/zenodo.20261027 |
| Etiketak: |
Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!
|
Aurkibidea:
- <p>This record contains raw data related to article “Generation of iPSC lines (ICHi001-A, ICHi002-A, ICHi003-A, ICHi004-A) from four patients carrying Titin truncating variants associated with dilated cardiomyopathy".</p> <h2 class="title">Abstract</h2> <div class="abstract-content selected"> <p>Inherited dilated cardiomyopathy (iDCM) is a disease of the heart muscle, characterized by left ventricle enlargement, systolic dysfunction and arrhythmias. iDCM represents a common cause of heart failure and the most frequent cause of heart transplantation. Among the causative genes, TTN, encoding the sarcomeric protein Titin, represents the most prevalent (about 25 % of cases). The heterogeneous clinical manifestations and variable response to therapy represent a major challenge in patients' clinical management. To deepen the knowledge of this disease, we generated and fully characterized induced Pluripotent Stem Cell lines from 4 iDCM patients carrying 4 different truncating variants of TTN gene.</p> </div>