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| Format: | Recurso digital |
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Zenodo
2026
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| Accès en ligne: | https://doi.org/10.5281/zenodo.20287126 |
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- <p class="MsoNormal"><span>Cardiometabolic disorders, including cardiovascular diseases, hypertension, obesity, dyslipidemia, insulin resistance, metabolic syndrome, and type 2 diabetes mellitus, represent a major global health burden due to their increasing prevalence and associated morbidity and mortality. Central pathophysiological processes driving these conditions include oxidative damage, persistent inflammatory responses, vascular endothelial impairment, and disrupted glucose and lipid homeostasis. Contemporary scientific attention has increasingly turned toward natural nutritional approaches and bioactive foods possessing broad-spectrum therapeutic capabilities. Within this context, garlic (Allium sativum L.) has distinguished itself as among the most thoroughly studied medicinal botanicals due to its varied pharmacological properties and abundant phytochemical profile. This plant harbors multiple bioactive components, notably organosulfur molecules including allicin, ajoene, diallyl sulfides, and S-allyl cysteine, alongside flavonoids, phenolic substances, vitamins, minerals, and saponins. These phytochemicals synergistically provide antioxidative, anti-inflammatory, lipid-lowering, blood pressure-reducing, glucose-regulating, anticoagulant, and vascular protective properties. Research demonstrates that garlic modulates various molecular signaling cascades, including NF-κB, Nrf2, AMPK, PI3K/Akt, and MAPK networks, </span><span>consequently diminishing oxidative damage, controlling inflammation, enhancing vascular performance, and promoting metabolic equilibrium. Furthermore, garlic affects nitric oxide and hydrogen sulfide transmission, platelet function, mitochondrial activity, and intestinal microbiome composition, thereby reinforcing its cardiovascular protective characteristics. This analysis provides a thorough examination of garlic's botanical characteristics, chemical constituents, mechanistic actions, and cardiometabolic benefits. It emphasizes existing obstacles regarding standardization, bioavailability, and clinical verification while exploring future directions for garlic-derived therapeutic approaches. In summary, garlic emerges as a valuable natural cardiometabolic guardian with considerable promise in preventive nutrition and integrative medicine.</span></p>