I tiakina i:
| Kaituhi matua: | |
|---|---|
| Hōputu: | Recurso digital |
| Reo: | Ingarihi |
| I whakaputaina: |
Zenodo
2026
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| Ngā marau: | |
| Urunga tuihono: | https://doi.org/10.5281/zenodo.20319946 |
| Ngā Tūtohu: |
Tāpirihia he Tūtohu
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
|
Rārangi ihirangi:
- <p>This conceptual systems-biology manuscript proposes that severe Ebola virus disease may reflect adaptive overcommitment of a reservoir-calibrated immune suppression strategy encountering a less tolerant human host environment. Building on Adaptive Overcommitment Theory (AOT), the paper reframes Ebola virulence as coupled destabilization of host coordination systems governing immune signaling, endothelial integrity, coagulation stability, hemodynamic resilience, and organ reserve. The framework integrates evolutionary mismatch theory, systems immunology, reservoir-host adaptation, and nonlinear host-collapse dynamics to explore how zoonotic virulence may emerge from host-specific overoptimization rather than primitive pathogenicity.</p>