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| Materyal Türü: | Recurso digital |
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Zenodo
2026
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| Konular: | |
| Online Erişim: | https://doi.org/10.5281/zenodo.20396013 |
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İçindekiler:
- <p class="MsoNormal"><span>Self-nanoemulsifying drug delivery systems (SNEDDS) have emerged as an extendable strategy to overcome the challenge that comes along with the drugs possessing low solubility, which are grouped under Biopharmaceutics Classification System (BCS) Class II and IV. Isotropic blends of oils, surfactants, and co-surfactants spontaneously create thin oil-in-water nanoemulsions (SNEDDS) on dilution in gastrointestinal fluids by mild agitation. The resulting droplets, commonly less than 200 nm in diameter, present a large surface area that maximizes solubilization and dissolution, hence increasing oral bioavailability. Beyond enhancing solubilization, SNEDDS promote lymphatic transport and minimize first-pass metabolism, further maximizing systemic exposure of the drug. The performance of the formulation depends heavily on the selection of oil phase, surfactant, and surfactant-to-co-surfactant ratio, which all control self-emulsification efficiency, droplet size, and stability. Progress in such areas as supersaturable SNEDDS and solid SNEDDS has broadened their utility. SNEDDS have shown consistent enhancements in drug candidate pharmacokinetic profiles, underpinned by well-documented in vitro testing and validation in vivo. In sum, SNEDDS form a strong, adaptable, and scalable platform with considerable potential for the oral delivery of next-generation drugs</span></p>