Accounting for selection bias due to death in estimating the effect of wealth shock on cognition for the Health and Retirement Study
Fuente:
arXiv
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Preprint |
| Published: |
2018
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866912586485727232 |
|---|---|
| author | Tan, Yaoyuan Vincent Flannagan, Carol A. C. Pool, Lindsay R. Elliott, Michael R. |
| author_facet | Tan, Yaoyuan Vincent Flannagan, Carol A. C. Pool, Lindsay R. Elliott, Michael R. |
| contents | The Health and Retirement Study is a longitudinal study of US adults enrolled at age 50 and older. We were interested in investigating the effect of a sudden large decline in wealth on the cognitive score of subjects. Our analysis was complicated by the lack of randomization, confounding by indication, and a substantial fraction of the sample and population will die during follow-up leading to some of our outcomes being censored. Common methods to handle these problems for example marginal structural models, may not be appropriate because it upweights subjects who are more likely to die to obtain a population that over time resembles that would have been obtained in the absence of death. We propose a refined approach by comparing the treatment effect among subjects who would survive under both sets of treatment regimes being considered. We do so by viewing this as a large missing data problem and impute the survival status and outcomes of the counterfactual. To improve the robustness of our imputation, we used a modified version of the penalized spline of propensity methods in treatment comparisons approach. We found that our proposed method worked well in various simulation scenarios and our data analysis. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_1812_08855 |
| institution | arXiv |
| publishDate | 2018 |
| record_format | arxiv |
| spellingShingle | Accounting for selection bias due to death in estimating the effect of wealth shock on cognition for the Health and Retirement Study Tan, Yaoyuan Vincent Flannagan, Carol A. C. Pool, Lindsay R. Elliott, Michael R. Applications The Health and Retirement Study is a longitudinal study of US adults enrolled at age 50 and older. We were interested in investigating the effect of a sudden large decline in wealth on the cognitive score of subjects. Our analysis was complicated by the lack of randomization, confounding by indication, and a substantial fraction of the sample and population will die during follow-up leading to some of our outcomes being censored. Common methods to handle these problems for example marginal structural models, may not be appropriate because it upweights subjects who are more likely to die to obtain a population that over time resembles that would have been obtained in the absence of death. We propose a refined approach by comparing the treatment effect among subjects who would survive under both sets of treatment regimes being considered. We do so by viewing this as a large missing data problem and impute the survival status and outcomes of the counterfactual. To improve the robustness of our imputation, we used a modified version of the penalized spline of propensity methods in treatment comparisons approach. We found that our proposed method worked well in various simulation scenarios and our data analysis. |
| title | Accounting for selection bias due to death in estimating the effect of wealth shock on cognition for the Health and Retirement Study |
| topic | Applications |
| url | https://arxiv.org/abs/1812.08855 |