Statistical significance revisited

Fuente: arXiv
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Autori principali: Tormählen, Maike, Klinkova, Galiya, Grabinski, Michael
Natura: Preprint
Pubblicazione: 2021
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author Tormählen, Maike
Klinkova, Galiya
Grabinski, Michael
author_facet Tormählen, Maike
Klinkova, Galiya
Grabinski, Michael
contents Statistical significance measures the reliability of a result obtained from a random experiment. We investigate the number of repetitions needed for a statistical result to have a certain significance. In the first step, we consider binomially distributed variables in the example of medication testing with fixed placebo efficacy, asking how many experiments are needed in order to achieve a significance of 95 %. In the next step, we take the probability distribution of the placebo efficacy into account, which to the best of our knowledge has not been done so far. Depending on the specifics, we show that in order to obtain identical significance, it may be necessary to perform twice as many experiments than in a setting where the placebo distribution is neglected. We proceed by considering more general probability distributions and close with comments on some erroneous assumptions on probability distributions which lead, for instance, to a trivial explanation of the fat tail.
format Preprint
id arxiv_https___arxiv_org_abs_2104_00262
institution arXiv
publishDate 2021
record_format arxiv
spellingShingle Statistical significance revisited
Tormählen, Maike
Klinkova, Galiya
Grabinski, Michael
Methodology
Statistical Finance
Applications
62Dxx
G.3
Statistical significance measures the reliability of a result obtained from a random experiment. We investigate the number of repetitions needed for a statistical result to have a certain significance. In the first step, we consider binomially distributed variables in the example of medication testing with fixed placebo efficacy, asking how many experiments are needed in order to achieve a significance of 95 %. In the next step, we take the probability distribution of the placebo efficacy into account, which to the best of our knowledge has not been done so far. Depending on the specifics, we show that in order to obtain identical significance, it may be necessary to perform twice as many experiments than in a setting where the placebo distribution is neglected. We proceed by considering more general probability distributions and close with comments on some erroneous assumptions on probability distributions which lead, for instance, to a trivial explanation of the fat tail.
title Statistical significance revisited
topic Methodology
Statistical Finance
Applications
62Dxx
G.3
url https://arxiv.org/abs/2104.00262