Hyperpolarized solution-state NMR spectroscopy with optically polarized crystals
Fuente:
arXiv
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Preprint |
| Publicado: |
2021
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1866909206285647872 |
|---|---|
| author | Eichhorn, Tim R. Parker, Anna J. Josten, Felix Müller, Christoph Scheuer, Jochen Steiner, Jakob M. Gierse, Martin Handwerker, Jonas Keim, Michael Lucas, Sebastian Qureshi, Mohammad Usman Marshall, Alastair Salhov, Alon Quan, Yifan Binder, Jan Jahnke, Kay Neumann, Philipp Knecht, Stephan Blanchard, John W. Plenio, Martin B. Jelezko, Fedor Emsley, Lyndon Vassiliou, Christophoros C. Hautle, Patrick Schwartz, Ilai |
| author_facet | Eichhorn, Tim R. Parker, Anna J. Josten, Felix Müller, Christoph Scheuer, Jochen Steiner, Jakob M. Gierse, Martin Handwerker, Jonas Keim, Michael Lucas, Sebastian Qureshi, Mohammad Usman Marshall, Alastair Salhov, Alon Quan, Yifan Binder, Jan Jahnke, Kay Neumann, Philipp Knecht, Stephan Blanchard, John W. Plenio, Martin B. Jelezko, Fedor Emsley, Lyndon Vassiliou, Christophoros C. Hautle, Patrick Schwartz, Ilai |
| contents | Nuclear spin hyperpolarization provides a promising route to overcome the challenges imposed by the limited sensitivity of nuclear magnetic resonance. Here we demonstrate that dissolution of spin-polarized pentacene-doped naphthalene crystals enables transfer of polarization to target molecules via intermolecular cross relaxation at room temperature and moderate magnetic fields (1.45$\,$T). This makes it possible to exploit the high spin polarization of optically polarized crystals while mitigating the challenges of its transfer to external nuclei, particularly of the large distances and prohibitively weak coupling between source and target nuclei across solid-solid or solid-liquid interfaces. With this method, here we inject the highly polarized mixture into a benchtop NMR spectrometer and observe the polarization dynamics for target $^1$H nuclei. Although the spectra are radiation damped due to the high naphthalene magnetization, we describe a procedure to process the data in order to obtain more conventional NMR spectra, and extract the target nuclei polarization. With the entire process occurring on a timescale of one minute, we observe NMR signals enhanced by factors between -200 and -1730 at 1.45$\,$T for a range of small molecules. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2108_06147 |
| institution | arXiv |
| publishDate | 2021 |
| record_format | arxiv |
| spellingShingle | Hyperpolarized solution-state NMR spectroscopy with optically polarized crystals Eichhorn, Tim R. Parker, Anna J. Josten, Felix Müller, Christoph Scheuer, Jochen Steiner, Jakob M. Gierse, Martin Handwerker, Jonas Keim, Michael Lucas, Sebastian Qureshi, Mohammad Usman Marshall, Alastair Salhov, Alon Quan, Yifan Binder, Jan Jahnke, Kay Neumann, Philipp Knecht, Stephan Blanchard, John W. Plenio, Martin B. Jelezko, Fedor Emsley, Lyndon Vassiliou, Christophoros C. Hautle, Patrick Schwartz, Ilai Chemical Physics Nuclear spin hyperpolarization provides a promising route to overcome the challenges imposed by the limited sensitivity of nuclear magnetic resonance. Here we demonstrate that dissolution of spin-polarized pentacene-doped naphthalene crystals enables transfer of polarization to target molecules via intermolecular cross relaxation at room temperature and moderate magnetic fields (1.45$\,$T). This makes it possible to exploit the high spin polarization of optically polarized crystals while mitigating the challenges of its transfer to external nuclei, particularly of the large distances and prohibitively weak coupling between source and target nuclei across solid-solid or solid-liquid interfaces. With this method, here we inject the highly polarized mixture into a benchtop NMR spectrometer and observe the polarization dynamics for target $^1$H nuclei. Although the spectra are radiation damped due to the high naphthalene magnetization, we describe a procedure to process the data in order to obtain more conventional NMR spectra, and extract the target nuclei polarization. With the entire process occurring on a timescale of one minute, we observe NMR signals enhanced by factors between -200 and -1730 at 1.45$\,$T for a range of small molecules. |
| title | Hyperpolarized solution-state NMR spectroscopy with optically polarized crystals |
| topic | Chemical Physics |
| url | https://arxiv.org/abs/2108.06147 |