The Lawnmower: an autonomous, protein-based artificial molecular motor
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| Main Authors: | , , , , , , , , |
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| Format: | Preprint |
| Published: |
2021
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| _version_ | 1866909333259812864 |
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| author | Korosec, Chapin S. Unksov, Ivan Surendiran, Pradheebha Lyttleton, Roman Curmi, Paul M. G. Angstmann, Christopher N. Eichhorn, Ralf Linke, Heiner Forde, Nancy R. |
| author_facet | Korosec, Chapin S. Unksov, Ivan Surendiran, Pradheebha Lyttleton, Roman Curmi, Paul M. G. Angstmann, Christopher N. Eichhorn, Ralf Linke, Heiner Forde, Nancy R. |
| contents | Inspired by biology, great progress has been made in creating artificial molecular motors. However, the dream of harnessing proteins - the building blocks selected by Nature - to design autonomous motors has so far remained elusive. Here we report the synthesis and characterization of the Lawnmower, an autonomous, protein-based artificial molecular motor comprised of a spherical hub decorated with proteases. Its "burnt-bridge" motion is directed by cleavage of a peptide lawn, promoting motion towards unvisited substrate. We find that Lawnmowers exhibit directional motion with average speeds of up to 80 nm/s, comparable to biological motors. By selectively patterning the peptide lawn on microfabricated tracks, we furthermore show that the Lawnmower is capable of track-guided motion. Our work opens an avenue towards nanotechnology applications of artificial protein motors. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2109_10293 |
| institution | arXiv |
| publishDate | 2021 |
| record_format | arxiv |
| spellingShingle | The Lawnmower: an autonomous, protein-based artificial molecular motor Korosec, Chapin S. Unksov, Ivan Surendiran, Pradheebha Lyttleton, Roman Curmi, Paul M. G. Angstmann, Christopher N. Eichhorn, Ralf Linke, Heiner Forde, Nancy R. Biological Physics Inspired by biology, great progress has been made in creating artificial molecular motors. However, the dream of harnessing proteins - the building blocks selected by Nature - to design autonomous motors has so far remained elusive. Here we report the synthesis and characterization of the Lawnmower, an autonomous, protein-based artificial molecular motor comprised of a spherical hub decorated with proteases. Its "burnt-bridge" motion is directed by cleavage of a peptide lawn, promoting motion towards unvisited substrate. We find that Lawnmowers exhibit directional motion with average speeds of up to 80 nm/s, comparable to biological motors. By selectively patterning the peptide lawn on microfabricated tracks, we furthermore show that the Lawnmower is capable of track-guided motion. Our work opens an avenue towards nanotechnology applications of artificial protein motors. |
| title | The Lawnmower: an autonomous, protein-based artificial molecular motor |
| topic | Biological Physics |
| url | https://arxiv.org/abs/2109.10293 |