Bayesian Model Calibration and Sensitivity Analysis for Oscillating Biological Experiments
Fuente:
arXiv
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Preprint |
| Published: |
2021
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866913610808164352 |
|---|---|
| author | Hwang, Youngdeok Kim, Hang J. Chang, Won Hong, Christian MacEachern, Steven N. |
| author_facet | Hwang, Youngdeok Kim, Hang J. Chang, Won Hong, Christian MacEachern, Steven N. |
| contents | Understanding the oscillating behaviors that govern organisms' internal biological processes requires interdisciplinary efforts combining both biological and computer experiments, as the latter can complement the former by simulating perturbed conditions with higher resolution. Harmonizing the two types of experiment, however, poses significant statistical challenges due to identifiability issues, numerical instability, and ill behavior in high dimension. This article devises a new Bayesian calibration framework for oscillating biochemical models. The proposed Bayesian model is estimated relying on an advanced Markov chain Monte Carlo (MCMC) technique which can efficiently infer the parameter values that match the simulated and observed oscillatory processes. Also proposed is an approach to sensitivity analysis based on the intervention posterior. This approach measures the influence of individual parameters on the target process by using the obtained MCMC samples as a computational tool. The proposed framework is illustrated with circadian oscillations observed in a filamentous fungus, Neurospora crassa. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2110_10604 |
| institution | arXiv |
| publishDate | 2021 |
| record_format | arxiv |
| spellingShingle | Bayesian Model Calibration and Sensitivity Analysis for Oscillating Biological Experiments Hwang, Youngdeok Kim, Hang J. Chang, Won Hong, Christian MacEachern, Steven N. Applications 62P10 (Primary), 62-08 (Secondary) Understanding the oscillating behaviors that govern organisms' internal biological processes requires interdisciplinary efforts combining both biological and computer experiments, as the latter can complement the former by simulating perturbed conditions with higher resolution. Harmonizing the two types of experiment, however, poses significant statistical challenges due to identifiability issues, numerical instability, and ill behavior in high dimension. This article devises a new Bayesian calibration framework for oscillating biochemical models. The proposed Bayesian model is estimated relying on an advanced Markov chain Monte Carlo (MCMC) technique which can efficiently infer the parameter values that match the simulated and observed oscillatory processes. Also proposed is an approach to sensitivity analysis based on the intervention posterior. This approach measures the influence of individual parameters on the target process by using the obtained MCMC samples as a computational tool. The proposed framework is illustrated with circadian oscillations observed in a filamentous fungus, Neurospora crassa. |
| title | Bayesian Model Calibration and Sensitivity Analysis for Oscillating Biological Experiments |
| topic | Applications 62P10 (Primary), 62-08 (Secondary) |
| url | https://arxiv.org/abs/2110.10604 |