Feature selection revisited in the single-cell era
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| Main Authors: | , , |
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| Format: | Preprint |
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2021
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| _version_ | 1866916093586571264 |
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| author | Yang, Pengyi Huang, Hao Liu, Chunlei |
| author_facet | Yang, Pengyi Huang, Hao Liu, Chunlei |
| contents | Feature selection techniques are essential for high-dimensional data analysis. In the last two decades, their popularity has been fuelled by the increasing availability of high-throughput biomolecular data where high-dimensionality is a common data property. Recent advances in biotechnologies enable global profiling of various molecular and cellular features at single-cell resolution, resulting in large-scale datasets with increased complexity. These technological developments have led to a resurgence in feature selection research and application in the single-cell field. Here, we revisit feature selection techniques and summarise recent developments. We review their versatile application to a range of single-cell data types including those generated from traditional cytometry and imaging technologies and the latest array of single-cell omics technologies. We highlight some of the challenges and future directions on which feature selection could have a significant impact. Finally, we consider the scalability and make general recommendations on the utility of each type of feature selection method. We hope this review serves as a reference point to stimulate future research and application of feature selection in the single-cell era. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2110_14329 |
| institution | arXiv |
| publishDate | 2021 |
| record_format | arxiv |
| spellingShingle | Feature selection revisited in the single-cell era Yang, Pengyi Huang, Hao Liu, Chunlei Quantitative Methods Machine Learning Feature selection techniques are essential for high-dimensional data analysis. In the last two decades, their popularity has been fuelled by the increasing availability of high-throughput biomolecular data where high-dimensionality is a common data property. Recent advances in biotechnologies enable global profiling of various molecular and cellular features at single-cell resolution, resulting in large-scale datasets with increased complexity. These technological developments have led to a resurgence in feature selection research and application in the single-cell field. Here, we revisit feature selection techniques and summarise recent developments. We review their versatile application to a range of single-cell data types including those generated from traditional cytometry and imaging technologies and the latest array of single-cell omics technologies. We highlight some of the challenges and future directions on which feature selection could have a significant impact. Finally, we consider the scalability and make general recommendations on the utility of each type of feature selection method. We hope this review serves as a reference point to stimulate future research and application of feature selection in the single-cell era. |
| title | Feature selection revisited in the single-cell era |
| topic | Quantitative Methods Machine Learning |
| url | https://arxiv.org/abs/2110.14329 |