Herding of proteins by the ends of shrinking polymers
Fuente:
arXiv
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| Autori principali: | , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | |
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| _version_ | 1866911504717053952 |
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| author | Al-Hiyasat, Amer Tuna, Yazgan Kuo, Yin-Wei Howard, Jonathon |
| author_facet | Al-Hiyasat, Amer Tuna, Yazgan Kuo, Yin-Wei Howard, Jonathon |
| contents | The control of biopolymer length is mediated by proteins that localize to polymer ends and regulate polymerization dynamics. Several mechanisms have been proposed to achieve end localization. Here, we propose a novel mechanism by which a protein that binds to a shrinking polymer and slows its shrinkage will be spontaneously enriched at the shrinking end through a "herding" effect. We formalize this process using both a lattice-gas model and a continuum description, and we present experimental evidence that the microtubule regulator spastin employs this mechanism. Our findings extend to more general problems involving diffusion within shrinking domains. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2112_07757 |
| institution | arXiv |
| publishDate | 2021 |
| record_format | arxiv |
| spellingShingle | Herding of proteins by the ends of shrinking polymers Al-Hiyasat, Amer Tuna, Yazgan Kuo, Yin-Wei Howard, Jonathon Biological Physics Subcellular Processes The control of biopolymer length is mediated by proteins that localize to polymer ends and regulate polymerization dynamics. Several mechanisms have been proposed to achieve end localization. Here, we propose a novel mechanism by which a protein that binds to a shrinking polymer and slows its shrinkage will be spontaneously enriched at the shrinking end through a "herding" effect. We formalize this process using both a lattice-gas model and a continuum description, and we present experimental evidence that the microtubule regulator spastin employs this mechanism. Our findings extend to more general problems involving diffusion within shrinking domains. |
| title | Herding of proteins by the ends of shrinking polymers |
| topic | Biological Physics Subcellular Processes |
| url | https://arxiv.org/abs/2112.07757 |