Cellular gradient flow structure connects single-cell-level rules and population-level dynamics
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arXiv
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| Autores principales: | , |
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| Formato: | Preprint |
| Publicado: |
2022
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| Acceso en línea: | |
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| _version_ | 1866913520466001920 |
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| author | Horiguchi, Shuhei A. Kobayashi, Tetsuya J. |
| author_facet | Horiguchi, Shuhei A. Kobayashi, Tetsuya J. |
| contents | In multicellular systems, the single-cell behaviors should be coordinated consistently with the overall population dynamics and functions. However, the interrelation between single-cell rules and the population-level goal is still elusive. In this work, we reveal that these two levels are naturally connected via a gradient flow structure of the heterogeneous cellular population and that biologically prevalent single-cell rules such as unidirectional type-switching and hierarchical order in types emerge from this structure. We also demonstrate the gradient flow structure in a standard model of the T-cell immune response. This theoretical framework works as a basis for understanding multicellular dynamics and functions. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2205_13143 |
| institution | arXiv |
| publishDate | 2022 |
| record_format | arxiv |
| spellingShingle | Cellular gradient flow structure connects single-cell-level rules and population-level dynamics Horiguchi, Shuhei A. Kobayashi, Tetsuya J. Populations and Evolution Cell Behavior In multicellular systems, the single-cell behaviors should be coordinated consistently with the overall population dynamics and functions. However, the interrelation between single-cell rules and the population-level goal is still elusive. In this work, we reveal that these two levels are naturally connected via a gradient flow structure of the heterogeneous cellular population and that biologically prevalent single-cell rules such as unidirectional type-switching and hierarchical order in types emerge from this structure. We also demonstrate the gradient flow structure in a standard model of the T-cell immune response. This theoretical framework works as a basis for understanding multicellular dynamics and functions. |
| title | Cellular gradient flow structure connects single-cell-level rules and population-level dynamics |
| topic | Populations and Evolution Cell Behavior |
| url | https://arxiv.org/abs/2205.13143 |