Myasthenia Gravis Diagnosis with Surface-enhanced Raman Spectroscopy
Fuente:
arXiv
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| Auteurs principaux: | , , , |
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| Format: | Preprint |
| Publié: |
2022
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| _version_ | 1866929680949444608 |
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| author | Riabenko, I. Prokhorenko, S. Klimova, E. Beloshenko, K. |
| author_facet | Riabenko, I. Prokhorenko, S. Klimova, E. Beloshenko, K. |
| contents | This study investigates the application of surface-enhanced Raman spectroscopy (SERS) as a diagnostic tool for myasthenia gravis, a severe neuromuscular disorder characterized by muscle weakness and fatigue. Blood serum samples were analyzed using SERS substrates embedded with 5 nm gold nanoparticles, resulting in significant Raman signal enhancement and the detection of disease-specific spectral features. The study demonstrates the potential of SERS to identify subtle biochemical changes associated with oxidative stress and altered molecular composition in serum, providing a sensitive and non-invasive approach for diagnosis. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2208_02014 |
| institution | arXiv |
| publishDate | 2022 |
| record_format | arxiv |
| spellingShingle | Myasthenia Gravis Diagnosis with Surface-enhanced Raman Spectroscopy Riabenko, I. Prokhorenko, S. Klimova, E. Beloshenko, K. Medical Physics Optics This study investigates the application of surface-enhanced Raman spectroscopy (SERS) as a diagnostic tool for myasthenia gravis, a severe neuromuscular disorder characterized by muscle weakness and fatigue. Blood serum samples were analyzed using SERS substrates embedded with 5 nm gold nanoparticles, resulting in significant Raman signal enhancement and the detection of disease-specific spectral features. The study demonstrates the potential of SERS to identify subtle biochemical changes associated with oxidative stress and altered molecular composition in serum, providing a sensitive and non-invasive approach for diagnosis. |
| title | Myasthenia Gravis Diagnosis with Surface-enhanced Raman Spectroscopy |
| topic | Medical Physics Optics |
| url | https://arxiv.org/abs/2208.02014 |