Neuro-evolutionary evidence for a universal fractal primate brain shape
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arXiv
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| Auteurs principaux: | , , , , , , , |
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| Format: | Preprint |
| Publié: |
2022
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| _version_ | 1866929437042278400 |
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| author | Wang, Yujiang Leiberg, Karoline Kindred, Nathan Madan, Christopher R. Poirier, Colline Petkov, Christopher I. Taylor, Peter N. Mota, Bruno C. C. |
| author_facet | Wang, Yujiang Leiberg, Karoline Kindred, Nathan Madan, Christopher R. Poirier, Colline Petkov, Christopher I. Taylor, Peter N. Mota, Bruno C. C. |
| contents | The cerebral cortex displays a bewildering diversity of shapes and sizes across and within species. Despite this diversity, we present a universal multi-scale description of primate cortices. We show that all cortical shapes can be described as a set of nested folds of different sizes. As neighbouring folds are gradually merged, the cortices of 11 primate species follow a common scale-free morphometric trajectory, that also overlaps with over 70 other mammalian species. Our results indicate that all cerebral cortices are approximations of the same archetypal fractal shape with a fractal dimension of $d_f=2.5$. Importantly, this new understanding enables a more precise quantification of brain morphology as a function of scale. To demonstrate the importance of this new understanding, we show a scale-dependent effect of ageing on brain morphology. We observe a more than four-fold increase in effect size (from 2 standard deviations to 8 standard deviations) at a spatial scale of approximately 2 mm compared to standard morphological analyses. Our new understanding may therefore generate superior biomarkers for a range of conditions in the future. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2209_08066 |
| institution | arXiv |
| publishDate | 2022 |
| record_format | arxiv |
| spellingShingle | Neuro-evolutionary evidence for a universal fractal primate brain shape Wang, Yujiang Leiberg, Karoline Kindred, Nathan Madan, Christopher R. Poirier, Colline Petkov, Christopher I. Taylor, Peter N. Mota, Bruno C. C. Neurons and Cognition The cerebral cortex displays a bewildering diversity of shapes and sizes across and within species. Despite this diversity, we present a universal multi-scale description of primate cortices. We show that all cortical shapes can be described as a set of nested folds of different sizes. As neighbouring folds are gradually merged, the cortices of 11 primate species follow a common scale-free morphometric trajectory, that also overlaps with over 70 other mammalian species. Our results indicate that all cerebral cortices are approximations of the same archetypal fractal shape with a fractal dimension of $d_f=2.5$. Importantly, this new understanding enables a more precise quantification of brain morphology as a function of scale. To demonstrate the importance of this new understanding, we show a scale-dependent effect of ageing on brain morphology. We observe a more than four-fold increase in effect size (from 2 standard deviations to 8 standard deviations) at a spatial scale of approximately 2 mm compared to standard morphological analyses. Our new understanding may therefore generate superior biomarkers for a range of conditions in the future. |
| title | Neuro-evolutionary evidence for a universal fractal primate brain shape |
| topic | Neurons and Cognition |
| url | https://arxiv.org/abs/2209.08066 |