A Text-guided Protein Design Framework
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arXiv
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Preprint |
| Published: |
2023
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| _version_ | 1866908406505275392 |
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| author | Liu, Shengchao Li, Yanjing Li, Zhuoxinran Gitter, Anthony Zhu, Yutao Lu, Jiarui Xu, Zhao Nie, Weili Ramanathan, Arvind Xiao, Chaowei Tang, Jian Guo, Hongyu Anandkumar, Anima |
| author_facet | Liu, Shengchao Li, Yanjing Li, Zhuoxinran Gitter, Anthony Zhu, Yutao Lu, Jiarui Xu, Zhao Nie, Weili Ramanathan, Arvind Xiao, Chaowei Tang, Jian Guo, Hongyu Anandkumar, Anima |
| contents | Current AI-assisted protein design mainly utilizes protein sequential and structural information. Meanwhile, there exists tremendous knowledge curated by humans in the text format describing proteins' high-level functionalities. Yet, whether the incorporation of such text data can help protein design tasks has not been explored. To bridge this gap, we propose ProteinDT, a multi-modal framework that leverages textual descriptions for protein design. ProteinDT consists of three subsequent steps: ProteinCLAP which aligns the representation of two modalities, a facilitator that generates the protein representation from the text modality, and a decoder that creates the protein sequences from the representation. To train ProteinDT, we construct a large dataset, SwissProtCLAP, with 441K text and protein pairs. We quantitatively verify the effectiveness of ProteinDT on three challenging tasks: (1) over 90% accuracy for text-guided protein generation; (2) best hit ratio on 12 zero-shot text-guided protein editing tasks; (3) superior performance on four out of six protein property prediction benchmarks. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2302_04611 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | A Text-guided Protein Design Framework Liu, Shengchao Li, Yanjing Li, Zhuoxinran Gitter, Anthony Zhu, Yutao Lu, Jiarui Xu, Zhao Nie, Weili Ramanathan, Arvind Xiao, Chaowei Tang, Jian Guo, Hongyu Anandkumar, Anima Machine Learning Artificial Intelligence Quantitative Methods Current AI-assisted protein design mainly utilizes protein sequential and structural information. Meanwhile, there exists tremendous knowledge curated by humans in the text format describing proteins' high-level functionalities. Yet, whether the incorporation of such text data can help protein design tasks has not been explored. To bridge this gap, we propose ProteinDT, a multi-modal framework that leverages textual descriptions for protein design. ProteinDT consists of three subsequent steps: ProteinCLAP which aligns the representation of two modalities, a facilitator that generates the protein representation from the text modality, and a decoder that creates the protein sequences from the representation. To train ProteinDT, we construct a large dataset, SwissProtCLAP, with 441K text and protein pairs. We quantitatively verify the effectiveness of ProteinDT on three challenging tasks: (1) over 90% accuracy for text-guided protein generation; (2) best hit ratio on 12 zero-shot text-guided protein editing tasks; (3) superior performance on four out of six protein property prediction benchmarks. |
| title | A Text-guided Protein Design Framework |
| topic | Machine Learning Artificial Intelligence Quantitative Methods |
| url | https://arxiv.org/abs/2302.04611 |