NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls
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arXiv
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| Auteurs principaux: | , , , , , |
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| Format: | Preprint |
| Publié: |
2023
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| _version_ | 1866913423656222720 |
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| author | Krotka, Pavla Hees, Katharina Jacko, Peter Magirr, Dominic Posch, Martin Roig, Marta Bofill |
| author_facet | Krotka, Pavla Hees, Katharina Jacko, Peter Magirr, Dominic Posch, Martin Roig, Marta Bofill |
| contents | Platform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in such trials can be improved by utilizing non-concurrent controls (NCC) in the analysis. We present the R-package NCC for the design and analysis of platform trials using non-concurrent controls. NCC allows for simulating platform trials and evaluating the properties of analysis methods that make use of non-concurrent controls in a variety of settings. We describe the main NCC functions and show how to use the package to simulate and analyse platform trials by means of specific examples. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2302_12634 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls Krotka, Pavla Hees, Katharina Jacko, Peter Magirr, Dominic Posch, Martin Roig, Marta Bofill Methodology Applications Platform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in such trials can be improved by utilizing non-concurrent controls (NCC) in the analysis. We present the R-package NCC for the design and analysis of platform trials using non-concurrent controls. NCC allows for simulating platform trials and evaluating the properties of analysis methods that make use of non-concurrent controls in a variety of settings. We describe the main NCC functions and show how to use the package to simulate and analyse platform trials by means of specific examples. |
| title | NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls |
| topic | Methodology Applications |
| url | https://arxiv.org/abs/2302.12634 |