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| Main Authors: | , , , , , |
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| Format: | Preprint |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2303.06119 |
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| _version_ | 1866929474965078016 |
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| author | Najar, Ulysse Barolle, Victor Balondrade, Paul Fink, Mathias Boccara, A. Claude Aubry, Alexandre |
| author_facet | Najar, Ulysse Barolle, Victor Balondrade, Paul Fink, Mathias Boccara, A. Claude Aubry, Alexandre |
| contents | As light travels through a disordered medium such as biological tissues, it undergoes multiple scattering events. This phenomenon is detrimental to in-depth optical microscopy, as it causes a drastic degradation of contrast, resolution and brightness of the resulting image beyond a few scattering mean free paths. However, the information about the inner reflectivity of the sample is not lost; only scrambled. To recover this information, a matrix approach of optical imaging can be fruitful. Here, we report on a de-scanned measurement of a high-dimension reflection matrix R via low coherence interferometry. Then, we show how a set of independent focusing laws can be extracted for each medium voxel through an iterative multi-scale analysis of wave distortions contained in R. It enables an optimal and local compensation of forward multiple scattering paths and provides a three-dimensional confocal image of the sample as the latter one had become digitally transparent. The proof-of-concept experiment is performed on a human opaque cornea and an extension of the penetration depth by a factor five is demonstrated compared to the state-of-the-art. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2303_06119 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | Harnessing Forward Multiple Scattering for Optical Imaging Deep Inside an Opaque Medium Najar, Ulysse Barolle, Victor Balondrade, Paul Fink, Mathias Boccara, A. Claude Aubry, Alexandre Optics As light travels through a disordered medium such as biological tissues, it undergoes multiple scattering events. This phenomenon is detrimental to in-depth optical microscopy, as it causes a drastic degradation of contrast, resolution and brightness of the resulting image beyond a few scattering mean free paths. However, the information about the inner reflectivity of the sample is not lost; only scrambled. To recover this information, a matrix approach of optical imaging can be fruitful. Here, we report on a de-scanned measurement of a high-dimension reflection matrix R via low coherence interferometry. Then, we show how a set of independent focusing laws can be extracted for each medium voxel through an iterative multi-scale analysis of wave distortions contained in R. It enables an optimal and local compensation of forward multiple scattering paths and provides a three-dimensional confocal image of the sample as the latter one had become digitally transparent. The proof-of-concept experiment is performed on a human opaque cornea and an extension of the penetration depth by a factor five is demonstrated compared to the state-of-the-art. |
| title | Harnessing Forward Multiple Scattering for Optical Imaging Deep Inside an Opaque Medium |
| topic | Optics |
| url | https://arxiv.org/abs/2303.06119 |