Transthoracic super-resolution ultrasound localisation microscopy of myocardial vasculature in patients
Fuente:
arXiv
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Preprint |
| Published: |
2023
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866909323517493248 |
|---|---|
| author | Yan, Jipeng Huang, Biao Tonko, Johanna Toulemonde, Matthieu Hansen-Shearer, Joseph Tan, Qingyuan Riemer, Kai Ntagiantas, Konstantinos Chowdhury, Rasheda A Lambiase, Pier Senior, Roxy Tang, Meng-Xing |
| author_facet | Yan, Jipeng Huang, Biao Tonko, Johanna Toulemonde, Matthieu Hansen-Shearer, Joseph Tan, Qingyuan Riemer, Kai Ntagiantas, Konstantinos Chowdhury, Rasheda A Lambiase, Pier Senior, Roxy Tang, Meng-Xing |
| contents | Micro-vascular flow in the myocardium is of significant importance clinically but remains poorly understood. Up to 25% of patients with symptoms of coronary heart diseases have no obstructive coronary arteries and have suspected microvascular diseases. However, such microvasculature is difficult to image in vivo with existing modalities due to the lack of resolution and sensitivity. Here, we demonstrate the feasibility of transthoracic super-resolution ultrasound localisation microscopy (SRUS/ULM) of myocardial microvasculature and hemodynamics in a large animal model and in patients, using a cardiac phased array probe with a customised data acquisition and processing pipeline. A multi-level motion correction strategy was proposed. A tracking framework incorporating multiple features and automatic parameter initialisations was developed to reconstruct microcirculation. In two patients with impaired myocardial function, we have generated SRUS images of myocardial vascular structure and flow with a resolution that is beyond the wave-diffraction limit (half a wavelength), using data acquired within a breath hold. Myocardial SRUS/ULM has potential to improve the understanding of myocardial microcirculation and the management of patients with cardiac microvascular diseases. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2303_14003 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | Transthoracic super-resolution ultrasound localisation microscopy of myocardial vasculature in patients Yan, Jipeng Huang, Biao Tonko, Johanna Toulemonde, Matthieu Hansen-Shearer, Joseph Tan, Qingyuan Riemer, Kai Ntagiantas, Konstantinos Chowdhury, Rasheda A Lambiase, Pier Senior, Roxy Tang, Meng-Xing Image and Video Processing Signal Processing Micro-vascular flow in the myocardium is of significant importance clinically but remains poorly understood. Up to 25% of patients with symptoms of coronary heart diseases have no obstructive coronary arteries and have suspected microvascular diseases. However, such microvasculature is difficult to image in vivo with existing modalities due to the lack of resolution and sensitivity. Here, we demonstrate the feasibility of transthoracic super-resolution ultrasound localisation microscopy (SRUS/ULM) of myocardial microvasculature and hemodynamics in a large animal model and in patients, using a cardiac phased array probe with a customised data acquisition and processing pipeline. A multi-level motion correction strategy was proposed. A tracking framework incorporating multiple features and automatic parameter initialisations was developed to reconstruct microcirculation. In two patients with impaired myocardial function, we have generated SRUS images of myocardial vascular structure and flow with a resolution that is beyond the wave-diffraction limit (half a wavelength), using data acquired within a breath hold. Myocardial SRUS/ULM has potential to improve the understanding of myocardial microcirculation and the management of patients with cardiac microvascular diseases. |
| title | Transthoracic super-resolution ultrasound localisation microscopy of myocardial vasculature in patients |
| topic | Image and Video Processing Signal Processing |
| url | https://arxiv.org/abs/2303.14003 |