Theory of rheology and aging of protein condensates
Fuente:
arXiv
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Preprint |
| Published: |
2023
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866910292357677056 |
|---|---|
| author | Takaki, Ryota Jawerth, Louise Popović, Marko Jülicher, Frank |
| author_facet | Takaki, Ryota Jawerth, Louise Popović, Marko Jülicher, Frank |
| contents | Biological condensates are assemblies of proteins and nucleic acids that form membraneless compartments in cells and play essential roles in cellular functions. In many cases they exhibit the physical properties of liquid droplets that coexist in a surrounding fluid. Recently, quantitative studies on the material properties of biological condensates have become available, revealing complex material properties. In vitro experiments have shown that protein condensates exhibit time dependent material properties, similar to aging in glasses. To understand this phenomenon from a theoretical perspective, we develop a rheological model based on the physical picture of protein diffusion and stochastic binding inside condensates. The complex nature of protein interactions is captured by a distribution of binding energies, incorporated in a trap model originally developed to study glass transitions. Our model can describe diffusion of constituent particles, as well as the material response to time-dependent forces, and it recapitulates the age dependent relaxation time of Maxwell glass observed experimentally both in active and passive rheology. We derive a generalized fluctuation-response relations of our model in which the relaxation function does not obey time translation invariance. Our study sheds light on the complex material properties of biological condensates and provides a theoretical framework for understanding their aging behavior. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2303_18028 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | Theory of rheology and aging of protein condensates Takaki, Ryota Jawerth, Louise Popović, Marko Jülicher, Frank Soft Condensed Matter Biological Physics Biological condensates are assemblies of proteins and nucleic acids that form membraneless compartments in cells and play essential roles in cellular functions. In many cases they exhibit the physical properties of liquid droplets that coexist in a surrounding fluid. Recently, quantitative studies on the material properties of biological condensates have become available, revealing complex material properties. In vitro experiments have shown that protein condensates exhibit time dependent material properties, similar to aging in glasses. To understand this phenomenon from a theoretical perspective, we develop a rheological model based on the physical picture of protein diffusion and stochastic binding inside condensates. The complex nature of protein interactions is captured by a distribution of binding energies, incorporated in a trap model originally developed to study glass transitions. Our model can describe diffusion of constituent particles, as well as the material response to time-dependent forces, and it recapitulates the age dependent relaxation time of Maxwell glass observed experimentally both in active and passive rheology. We derive a generalized fluctuation-response relations of our model in which the relaxation function does not obey time translation invariance. Our study sheds light on the complex material properties of biological condensates and provides a theoretical framework for understanding their aging behavior. |
| title | Theory of rheology and aging of protein condensates |
| topic | Soft Condensed Matter Biological Physics |
| url | https://arxiv.org/abs/2303.18028 |