Homogeneity Tests and Interval Estimations of Risk Differences for Stratified Bilateral and Unilateral Correlated Data
Fuente:
arXiv
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Preprint |
| Published: |
2023
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866911788903170048 |
|---|---|
| author | Liang, Shuyi Fang, Kai-Tai Huang, Xin-Wei Xin, Yijing Ma, Chang-Xing |
| author_facet | Liang, Shuyi Fang, Kai-Tai Huang, Xin-Wei Xin, Yijing Ma, Chang-Xing |
| contents | In clinical trials studying paired parts of a subject with binary outcomes, it is expected to collect measurements bilaterally. However, there are cases where subjects contribute measurements for only one part. By utilizing combined data, it is possible to gain additional information compared to using bilateral or unilateral data alone. With the combined data, this article investigates homogeneity tests of risk differences with the presence of stratification effects and proposes interval estimations of a common risk difference if stratification does not introduce underlying dissimilarities. Under Dallal's model \citeyearpar{dallal1988paired}, we propose three test statistics and evaluate their performances regarding type I error controls and powers. Confidence intervals of a common risk difference with satisfactory coverage probabilities and interval length are constructed. Our simulation results show that the score test is the most robust and the profile likelihood confidence interval outperforms other methods proposed. Data from a study of acute otitis media is used to illustrate our proposed procedures. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2304_00162 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | Homogeneity Tests and Interval Estimations of Risk Differences for Stratified Bilateral and Unilateral Correlated Data Liang, Shuyi Fang, Kai-Tai Huang, Xin-Wei Xin, Yijing Ma, Chang-Xing Applications In clinical trials studying paired parts of a subject with binary outcomes, it is expected to collect measurements bilaterally. However, there are cases where subjects contribute measurements for only one part. By utilizing combined data, it is possible to gain additional information compared to using bilateral or unilateral data alone. With the combined data, this article investigates homogeneity tests of risk differences with the presence of stratification effects and proposes interval estimations of a common risk difference if stratification does not introduce underlying dissimilarities. Under Dallal's model \citeyearpar{dallal1988paired}, we propose three test statistics and evaluate their performances regarding type I error controls and powers. Confidence intervals of a common risk difference with satisfactory coverage probabilities and interval length are constructed. Our simulation results show that the score test is the most robust and the profile likelihood confidence interval outperforms other methods proposed. Data from a study of acute otitis media is used to illustrate our proposed procedures. |
| title | Homogeneity Tests and Interval Estimations of Risk Differences for Stratified Bilateral and Unilateral Correlated Data |
| topic | Applications |
| url | https://arxiv.org/abs/2304.00162 |