Approximation and stability results for the parabolic FitzHugh-Nagumo system with combined rapidly oscillating sources

Fuente: arXiv
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Main Authors: Cerpa, Eduardo, Courdurier, Matías, Hernández, Esteban, Medina, Leonel E., Paduro, Esteban
Format: Preprint
Published: 2023
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author Cerpa, Eduardo
Courdurier, Matías
Hernández, Esteban
Medina, Leonel E.
Paduro, Esteban
author_facet Cerpa, Eduardo
Courdurier, Matías
Hernández, Esteban
Medina, Leonel E.
Paduro, Esteban
contents The use of high-frequency currents in neurostimulation has received increased attention in recent years due to its varied effects on tissues and cells. Nonlinear differential equations are commonly used as models for Neurons, and averaging methods are suitable for addressing questions like stability when considering single-frequency sources. A recent strategy called temporal interference stimulation uses electrodes to deliver sinusoidal signals of slightly different frequencies. Thus, classical averaging cannot be directly applied. This paper considers the one-dimensional FitzHugh-Nagumo system under the effects of a source composed of two sinusoidal terms in time and decaying in space. We develop a new averaging strategy to show that the solution of the system can be approximated by an explicit highly-oscillatory term plus the solution of a simpler, non-autonomous system. One of the main novelties is an extension of the contracting rectangles method to the case of parabolic equations with space and time-depending coefficients.
format Preprint
id arxiv_https___arxiv_org_abs_2305_00123
institution arXiv
publishDate 2023
record_format arxiv
spellingShingle Approximation and stability results for the parabolic FitzHugh-Nagumo system with combined rapidly oscillating sources
Cerpa, Eduardo
Courdurier, Matías
Hernández, Esteban
Medina, Leonel E.
Paduro, Esteban
Analysis of PDEs
35Q92, 35K55
The use of high-frequency currents in neurostimulation has received increased attention in recent years due to its varied effects on tissues and cells. Nonlinear differential equations are commonly used as models for Neurons, and averaging methods are suitable for addressing questions like stability when considering single-frequency sources. A recent strategy called temporal interference stimulation uses electrodes to deliver sinusoidal signals of slightly different frequencies. Thus, classical averaging cannot be directly applied. This paper considers the one-dimensional FitzHugh-Nagumo system under the effects of a source composed of two sinusoidal terms in time and decaying in space. We develop a new averaging strategy to show that the solution of the system can be approximated by an explicit highly-oscillatory term plus the solution of a simpler, non-autonomous system. One of the main novelties is an extension of the contracting rectangles method to the case of parabolic equations with space and time-depending coefficients.
title Approximation and stability results for the parabolic FitzHugh-Nagumo system with combined rapidly oscillating sources
topic Analysis of PDEs
35Q92, 35K55
url https://arxiv.org/abs/2305.00123