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| Main Authors: | , , , , |
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| Format: | Preprint |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2305.08266 |
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| _version_ | 1866917585897914368 |
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| author | Wang, Geng Shi, Jindou Iyer, Rishyashring R. Sorrells, Janet E. Tu, Haohua |
| author_facet | Wang, Geng Shi, Jindou Iyer, Rishyashring R. Sorrells, Janet E. Tu, Haohua |
| contents | Broad and safe access to ultrafast laser technology has been hindered by the absence of optical fiber-delivered pulses with tunable central wavelength, pulse repetition rate, and pulse width in the picosecond-femtosecond regime. To address this long-standing obstacle, we developed a reliable accessory for femtosecond ytterbium fiber chirped pulse amplifiers, termed as fiber-optic nonlinear wavelength converter (FNWC), as an adaptive optical source for the emergent field of femtosecond biophotonics. This accessory embowers the fixed-wavelength laser to produce fiber delivered ~20 nJ pulses with central wavelength across 950-1150 nm, repetition rate across 1-10 MHz, and pulse width across 40-400 fs, with a long-term stability of >2000 hrs. As a prototypical label-free application in biology and medicine, we demonstrate the utility of FNWC in real-time intravital imaging synergistically integrated with modern machine learning and large-scale fluorescence lifetime imaging microscopy. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2305_08266 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | Fiber-optic nonlinear wavelength converter for adaptive femtosecond biophotonics Wang, Geng Shi, Jindou Iyer, Rishyashring R. Sorrells, Janet E. Tu, Haohua Optics Broad and safe access to ultrafast laser technology has been hindered by the absence of optical fiber-delivered pulses with tunable central wavelength, pulse repetition rate, and pulse width in the picosecond-femtosecond regime. To address this long-standing obstacle, we developed a reliable accessory for femtosecond ytterbium fiber chirped pulse amplifiers, termed as fiber-optic nonlinear wavelength converter (FNWC), as an adaptive optical source for the emergent field of femtosecond biophotonics. This accessory embowers the fixed-wavelength laser to produce fiber delivered ~20 nJ pulses with central wavelength across 950-1150 nm, repetition rate across 1-10 MHz, and pulse width across 40-400 fs, with a long-term stability of >2000 hrs. As a prototypical label-free application in biology and medicine, we demonstrate the utility of FNWC in real-time intravital imaging synergistically integrated with modern machine learning and large-scale fluorescence lifetime imaging microscopy. |
| title | Fiber-optic nonlinear wavelength converter for adaptive femtosecond biophotonics |
| topic | Optics |
| url | https://arxiv.org/abs/2305.08266 |