Approximation and existence of a viscoelastic phase-field model for tumour growth in two and three dimensions
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| Format: | Preprint |
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2023
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| _version_ | 1866916294462275584 |
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| author | Garcke, Harald Trautwein, Dennis |
| author_facet | Garcke, Harald Trautwein, Dennis |
| contents | In this work, we present a phase-field model for tumour growth, where a diffuse interface separates a tumour from the surrounding host tissue. In our model, we consider transport processes by an internal, non-solenoidal velocity field. We include viscoelastic effects with the help of a general Oldroyd-B type description with relaxation and possible stress generation by growth. The elastic energy density is coupled to the phase-field variable which allows to model invasive growth towards areas with less mechanical resistance. The main analytical result is the existence of weak solutions in two and three space dimensions in the case of additional stress diffusion. The idea behind the proof is to use a numerical approximation with a fully-practical, stable and (subsequence) converging finite element scheme. The physical properties of the model are preserved with the help of a regularization technique, uniform estimates and a limit passage on the fully-discrete level. Finally, we illustrate the practicability of the discrete scheme with the help of numerical simulations in two and three dimensions. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2305_14915 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | Approximation and existence of a viscoelastic phase-field model for tumour growth in two and three dimensions Garcke, Harald Trautwein, Dennis Numerical Analysis 65M12, 65M60, 76A10, 35Q92, 35K35 In this work, we present a phase-field model for tumour growth, where a diffuse interface separates a tumour from the surrounding host tissue. In our model, we consider transport processes by an internal, non-solenoidal velocity field. We include viscoelastic effects with the help of a general Oldroyd-B type description with relaxation and possible stress generation by growth. The elastic energy density is coupled to the phase-field variable which allows to model invasive growth towards areas with less mechanical resistance. The main analytical result is the existence of weak solutions in two and three space dimensions in the case of additional stress diffusion. The idea behind the proof is to use a numerical approximation with a fully-practical, stable and (subsequence) converging finite element scheme. The physical properties of the model are preserved with the help of a regularization technique, uniform estimates and a limit passage on the fully-discrete level. Finally, we illustrate the practicability of the discrete scheme with the help of numerical simulations in two and three dimensions. |
| title | Approximation and existence of a viscoelastic phase-field model for tumour growth in two and three dimensions |
| topic | Numerical Analysis 65M12, 65M60, 76A10, 35Q92, 35K35 |
| url | https://arxiv.org/abs/2305.14915 |