Poissonian cellular Potts models reveal nonequilibrium kinetics of cell sorting
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arXiv
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| Hauptverfasser: | , , , , , |
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| Format: | Preprint |
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2023
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| _version_ | 1866913899460165632 |
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| author | Belousov, Roman Savino, Sabrina Moghe, Prachiti Hiiragi, Takashi Rondoni, Lamberto Erzberger, Anna |
| author_facet | Belousov, Roman Savino, Sabrina Moghe, Prachiti Hiiragi, Takashi Rondoni, Lamberto Erzberger, Anna |
| contents | Cellular Potts models are broadly applied across developmental biology and cancer research. We overcome limitations of the traditional approach, which reinterprets a modified Metropolis sampling as ad hoc dynamics, by introducing a physical timescale through Poissonian kinetics and by applying principles of stochastic thermodynamics to separate thermal and relaxation effects from athermal noise and nonconservative forces. Our method accurately describes cell-sorting dynamics in mouse-embryo development and identifies the distinct contributions of nonequilibrium processes, e.g. cell growth and active fluctuations. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2306_04443 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | Poissonian cellular Potts models reveal nonequilibrium kinetics of cell sorting Belousov, Roman Savino, Sabrina Moghe, Prachiti Hiiragi, Takashi Rondoni, Lamberto Erzberger, Anna Statistical Mechanics Biological Physics Cellular Potts models are broadly applied across developmental biology and cancer research. We overcome limitations of the traditional approach, which reinterprets a modified Metropolis sampling as ad hoc dynamics, by introducing a physical timescale through Poissonian kinetics and by applying principles of stochastic thermodynamics to separate thermal and relaxation effects from athermal noise and nonconservative forces. Our method accurately describes cell-sorting dynamics in mouse-embryo development and identifies the distinct contributions of nonequilibrium processes, e.g. cell growth and active fluctuations. |
| title | Poissonian cellular Potts models reveal nonequilibrium kinetics of cell sorting |
| topic | Statistical Mechanics Biological Physics |
| url | https://arxiv.org/abs/2306.04443 |