Survival of the flattest in the quasispecies model
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arXiv
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| Natura: | Preprint |
| Pubblicazione: |
2023
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| author | Berger, Maxime Cerf, Raphaël |
| author_facet | Berger, Maxime Cerf, Raphaël |
| contents | Viruses present an amazing genetic variability. An ensemble of infecting viruses, also called a viral quasispecies, is a cloud of mutants centered around a specific genotype. The simplest model of evolution, whose equilibrium state is described by the quasispecies equation, is the Moran--Kingman model. For the sharp peak landscape, we perform several exact computations and we derive several exact formulas. We obtain also an exact formula for the quasispecies distribution, involving a series and the mean fitness. A very simple formula for the mean Hamming distance is derived, which is exact and which do not require a specific asymptotic expansion (like sending the length of the macromolecules to $\infty$ or the mutation probability to $0$). We try also to extend these formulas to a general fitness landscape. We obtain an equation involving the covariance of the fitness and the Hamming class number in the quasispecies distribution. With the help of these formulas, we discuss the phenomenon of the error threshold and the notion of quasispecies. We recover the limiting quasipecies distribution in the long chain regime. We go beyond the sharp peak landscape and we consider fitness landscapes having finitely many peaks and a plateau--type landscape. We finally prove rigorously within this framework the possible occurrence of the survival of the flattest, a phenomenon which has been previously discovered by Wilke, Wang, Ofria, Lenski and Adami and which has been investigated in several works. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2306_09221 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | Survival of the flattest in the quasispecies model Berger, Maxime Cerf, Raphaël Populations and Evolution Probability Viruses present an amazing genetic variability. An ensemble of infecting viruses, also called a viral quasispecies, is a cloud of mutants centered around a specific genotype. The simplest model of evolution, whose equilibrium state is described by the quasispecies equation, is the Moran--Kingman model. For the sharp peak landscape, we perform several exact computations and we derive several exact formulas. We obtain also an exact formula for the quasispecies distribution, involving a series and the mean fitness. A very simple formula for the mean Hamming distance is derived, which is exact and which do not require a specific asymptotic expansion (like sending the length of the macromolecules to $\infty$ or the mutation probability to $0$). We try also to extend these formulas to a general fitness landscape. We obtain an equation involving the covariance of the fitness and the Hamming class number in the quasispecies distribution. With the help of these formulas, we discuss the phenomenon of the error threshold and the notion of quasispecies. We recover the limiting quasipecies distribution in the long chain regime. We go beyond the sharp peak landscape and we consider fitness landscapes having finitely many peaks and a plateau--type landscape. We finally prove rigorously within this framework the possible occurrence of the survival of the flattest, a phenomenon which has been previously discovered by Wilke, Wang, Ofria, Lenski and Adami and which has been investigated in several works. |
| title | Survival of the flattest in the quasispecies model |
| topic | Populations and Evolution Probability |
| url | https://arxiv.org/abs/2306.09221 |