The Core & Periphery Hypothesis: A Conceptual Basis for Generality in Cell and Developmental Biology
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| Main Authors: | , , , , |
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| Format: | Preprint |
| Published: |
2023
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| _version_ | 1866913510134382592 |
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| author | Gallo, Elisa De Renzis, Stefano Sharpe, James Mayor, Roberto Hartmann, Jonas |
| author_facet | Gallo, Elisa De Renzis, Stefano Sharpe, James Mayor, Roberto Hartmann, Jonas |
| contents | The discovery of general principles underlying the complexity and diversity of cellular and developmental systems is a central and long-standing aim of biology. Whilst new technologies collect data at an ever-accelerating rate, there is growing concern that conceptual progress is not keeping pace. We contend that this is due to a paucity of appropriate conceptual frameworks to serve as a basis for general theories of mesoscale biological phenomena. In exploring this issue, we have developed a foundation for one such framework, termed the Core and Periphery (C&P) hypothesis, which reveals hidden generality across the diverse and complex behaviors exhibited by cells and tissues. Here, we present the C&P concept, provide examples of its applicability across multiple scales, argue its consistency with evolution, and discuss key implications and open questions. We propose that the C&P hypothesis could unlock new avenues of conceptual progress in cell and developmental biology. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2306_09534 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | The Core & Periphery Hypothesis: A Conceptual Basis for Generality in Cell and Developmental Biology Gallo, Elisa De Renzis, Stefano Sharpe, James Mayor, Roberto Hartmann, Jonas Cell Behavior Populations and Evolution Subcellular Processes The discovery of general principles underlying the complexity and diversity of cellular and developmental systems is a central and long-standing aim of biology. Whilst new technologies collect data at an ever-accelerating rate, there is growing concern that conceptual progress is not keeping pace. We contend that this is due to a paucity of appropriate conceptual frameworks to serve as a basis for general theories of mesoscale biological phenomena. In exploring this issue, we have developed a foundation for one such framework, termed the Core and Periphery (C&P) hypothesis, which reveals hidden generality across the diverse and complex behaviors exhibited by cells and tissues. Here, we present the C&P concept, provide examples of its applicability across multiple scales, argue its consistency with evolution, and discuss key implications and open questions. We propose that the C&P hypothesis could unlock new avenues of conceptual progress in cell and developmental biology. |
| title | The Core & Periphery Hypothesis: A Conceptual Basis for Generality in Cell and Developmental Biology |
| topic | Cell Behavior Populations and Evolution Subcellular Processes |
| url | https://arxiv.org/abs/2306.09534 |