The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus
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arXiv
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| Autores principales: | , , , |
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| Formato: | Preprint |
| Publicado: |
2023
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| Acceso en línea: | |
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| _version_ | 1866913104975101952 |
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| author | Li, Xiangting Habibipour, Sara Chou, Tom Yang, Otto O. |
| author_facet | Li, Xiangting Habibipour, Sara Chou, Tom Yang, Otto O. |
| contents | Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing, compared to MPXV genomes collected earlier. It is unclear whether these single nucleotide polymorphisms (SNPs) result from APOBEC3-induced editing or are a consequence of genetic drift within one or more MPXV animal reservoirs. We develop a simple method based on a generalization of the General-Time-Reversible (GTR) model to show that the observed SNPs are likely the result of APOBEC3-induced editing. The statistical features allow us to extract lineage information and estimate evolutionary events. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2308_03714 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus Li, Xiangting Habibipour, Sara Chou, Tom Yang, Otto O. Populations and Evolution Statistical Mechanics Genomics Quantitative Methods Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing, compared to MPXV genomes collected earlier. It is unclear whether these single nucleotide polymorphisms (SNPs) result from APOBEC3-induced editing or are a consequence of genetic drift within one or more MPXV animal reservoirs. We develop a simple method based on a generalization of the General-Time-Reversible (GTR) model to show that the observed SNPs are likely the result of APOBEC3-induced editing. The statistical features allow us to extract lineage information and estimate evolutionary events. |
| title | The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus |
| topic | Populations and Evolution Statistical Mechanics Genomics Quantitative Methods |
| url | https://arxiv.org/abs/2308.03714 |