Determining Sources in the Bioluminescence Tomography Problem
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arXiv
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| Autori principali: | , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2023
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| _version_ | 1866918017808465920 |
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| author | Ding, Ming-Hui Gong, Rongfang Liu, Hongyu Lo, Catharine W. K. |
| author_facet | Ding, Ming-Hui Gong, Rongfang Liu, Hongyu Lo, Catharine W. K. |
| contents | In this paper, we revisit the bioluminescence tomography (BLT) problem, where one seeks to reconstruct bioluminescence signals (an internal light source) from external measurements of the Cauchy data. As one kind of optical imaging, the BLT has many merits such as high signal-to-noise ratio, non-destructivity and cost-effectiveness etc., and has potential applications such as cancer diagnosis, drug discovery and development as well as gene therapies and so on. In the literature, BLT is extensively studied based on diffusion approximation (DA) equation, where the distribution of peak sources is to be reconstructed and no solution uniqueness is guaranteed without adequate a priori information. Motivated by the solution uniqueness issue, several theoretical results are explored. The major contributions in this work that are new to the literature are two-fold: first, we show the theoretical uniqueness of the BLT problem where the light sources are in the shape of $C^2$ domains or polyhedral- or corona-shaped; second, we support our results with plenty of problem-orientated numerical experiments. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2311_05191 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | Determining Sources in the Bioluminescence Tomography Problem Ding, Ming-Hui Gong, Rongfang Liu, Hongyu Lo, Catharine W. K. Analysis of PDEs Numerical Analysis Primary 35R30, secondary 78A46, 92C55, 35Q60, 78A70 In this paper, we revisit the bioluminescence tomography (BLT) problem, where one seeks to reconstruct bioluminescence signals (an internal light source) from external measurements of the Cauchy data. As one kind of optical imaging, the BLT has many merits such as high signal-to-noise ratio, non-destructivity and cost-effectiveness etc., and has potential applications such as cancer diagnosis, drug discovery and development as well as gene therapies and so on. In the literature, BLT is extensively studied based on diffusion approximation (DA) equation, where the distribution of peak sources is to be reconstructed and no solution uniqueness is guaranteed without adequate a priori information. Motivated by the solution uniqueness issue, several theoretical results are explored. The major contributions in this work that are new to the literature are two-fold: first, we show the theoretical uniqueness of the BLT problem where the light sources are in the shape of $C^2$ domains or polyhedral- or corona-shaped; second, we support our results with plenty of problem-orientated numerical experiments. |
| title | Determining Sources in the Bioluminescence Tomography Problem |
| topic | Analysis of PDEs Numerical Analysis Primary 35R30, secondary 78A46, 92C55, 35Q60, 78A70 |
| url | https://arxiv.org/abs/2311.05191 |