Experimental demonstration of mice tumor control with a laser-accelerated high-energy electron radiotherapy prototype
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arXiv
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| Autores principales: | , , , , , , , , , , , |
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| Formato: | Preprint |
| Publicado: |
2023
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| _version_ | 1866912271549071360 |
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| author | Guo, Zhiyuan Liu, Shuang Zhou, Bing Liu, Junqi Wang, Haiyang Wan, Yang Pi, Yifei Wang, Xiaoyan Mo, Yingyi Guo, Bo Hua, Jianfei Lu, Wei |
| author_facet | Guo, Zhiyuan Liu, Shuang Zhou, Bing Liu, Junqi Wang, Haiyang Wan, Yang Pi, Yifei Wang, Xiaoyan Mo, Yingyi Guo, Bo Hua, Jianfei Lu, Wei |
| contents | Radiotherapy using very-high-energy electron (VHEE) beams (50-300 MeV) has attracted considerable attention due to its advantageous dose deposition characteristics, enabling deep penetration and the potential for ultra-high dose rate treatment. One promising approach to compactly delivering these high energy electron beams in a cost-effective manner is laser wakefield acceleration (LWFA), which offers ultra-strong accelerating gradients. However, the transition from this concept to a functional machine intended for tumor treatment is still being investigated. Here we present the first self-developed prototype for LWFA-based VHEE radiotherapy, exhibiting high compactness (occupying less than 5 square meters) and high operational stability (validated over a period of one month). Subsequently, we employed this device to irradiate a tumor implanted in a mouse model. Following a dose delivery of $5.8\pm0.2$ Gy with precise tumor conformity, all irradiated mice exhibited pronounced control of tumor growth. For comparison, this tumor-control efficacy was similar to that achieved using commercial X-ray radiotherapy equipment operating at equivalent doses. These results demonstrate the potential of a compact laser-driven VHEE system for preclinical studies involving small animal models and its promising prospects for future clinical translation in cancer therapy. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2312_03481 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | Experimental demonstration of mice tumor control with a laser-accelerated high-energy electron radiotherapy prototype Guo, Zhiyuan Liu, Shuang Zhou, Bing Liu, Junqi Wang, Haiyang Wan, Yang Pi, Yifei Wang, Xiaoyan Mo, Yingyi Guo, Bo Hua, Jianfei Lu, Wei Medical Physics Accelerator Physics Optics Plasma Physics Radiotherapy using very-high-energy electron (VHEE) beams (50-300 MeV) has attracted considerable attention due to its advantageous dose deposition characteristics, enabling deep penetration and the potential for ultra-high dose rate treatment. One promising approach to compactly delivering these high energy electron beams in a cost-effective manner is laser wakefield acceleration (LWFA), which offers ultra-strong accelerating gradients. However, the transition from this concept to a functional machine intended for tumor treatment is still being investigated. Here we present the first self-developed prototype for LWFA-based VHEE radiotherapy, exhibiting high compactness (occupying less than 5 square meters) and high operational stability (validated over a period of one month). Subsequently, we employed this device to irradiate a tumor implanted in a mouse model. Following a dose delivery of $5.8\pm0.2$ Gy with precise tumor conformity, all irradiated mice exhibited pronounced control of tumor growth. For comparison, this tumor-control efficacy was similar to that achieved using commercial X-ray radiotherapy equipment operating at equivalent doses. These results demonstrate the potential of a compact laser-driven VHEE system for preclinical studies involving small animal models and its promising prospects for future clinical translation in cancer therapy. |
| title | Experimental demonstration of mice tumor control with a laser-accelerated high-energy electron radiotherapy prototype |
| topic | Medical Physics Accelerator Physics Optics Plasma Physics |
| url | https://arxiv.org/abs/2312.03481 |