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| Auteurs principaux: | , , , |
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| Format: | Preprint |
| Publié: |
2023
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| Sujets: | |
| Accès en ligne: | https://arxiv.org/abs/2312.07172 |
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| _version_ | 1866916350118592512 |
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| author | Nandi, Mintu Chattopadhyay, Sudip Bandyopadhyay, Somshubhro Banik, Suman K |
| author_facet | Nandi, Mintu Chattopadhyay, Sudip Bandyopadhyay, Somshubhro Banik, Suman K |
| contents | Signal propagation in biochemical networks is characterized by the inherent randomness in gene expression and fluctuations of the environmental components, commonly known as intrinsic and extrinsic noise, respectively. We present a theoretical framework for noise propagation in a generic two-step cascade (S$\rightarrow$X$\rightarrow$Y) regarding intrinsic and extrinsic noise. We identify different channels of noise transmission that regulate the individual and the overall noise properties of each component. Our analysis shows that the intrinsic noise of S alleviates the general noise and information transmission capacity along the cascade. On the other hand, the intrinsic noise of X and Y acts as a bottleneck of information transmission. We also show a hierarchical relationship among the intrinsic noise levels of S, X, and Y, with S exhibiting the highest level of intrinsic noise, followed by X and then Y. This hierarchy is preserved within the two-step cascade, facilitating the highest information transmission from S to Y via X. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2312_07172 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | Channel assisted noise propagation in a two-step cascade Nandi, Mintu Chattopadhyay, Sudip Bandyopadhyay, Somshubhro Banik, Suman K Molecular Networks Biological Physics Signal propagation in biochemical networks is characterized by the inherent randomness in gene expression and fluctuations of the environmental components, commonly known as intrinsic and extrinsic noise, respectively. We present a theoretical framework for noise propagation in a generic two-step cascade (S$\rightarrow$X$\rightarrow$Y) regarding intrinsic and extrinsic noise. We identify different channels of noise transmission that regulate the individual and the overall noise properties of each component. Our analysis shows that the intrinsic noise of S alleviates the general noise and information transmission capacity along the cascade. On the other hand, the intrinsic noise of X and Y acts as a bottleneck of information transmission. We also show a hierarchical relationship among the intrinsic noise levels of S, X, and Y, with S exhibiting the highest level of intrinsic noise, followed by X and then Y. This hierarchy is preserved within the two-step cascade, facilitating the highest information transmission from S to Y via X. |
| title | Channel assisted noise propagation in a two-step cascade |
| topic | Molecular Networks Biological Physics |
| url | https://arxiv.org/abs/2312.07172 |