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| Autori principali: | , , , , , , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2023
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| Soggetti: | |
| Accesso online: | https://arxiv.org/abs/2312.17603 |
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| _version_ | 1866917883647361024 |
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| author | Oshimi, Keisuke Nakashima, Hiromu Mandić, Sara Kobayashi, Hina Teramoto, Minori Tsuji, Hirokazu Nishibayashi, Yoshiki Shikano, Yutaka An, Toshu Fujiwara, Masazumi |
| author_facet | Oshimi, Keisuke Nakashima, Hiromu Mandić, Sara Kobayashi, Hina Teramoto, Minori Tsuji, Hirokazu Nishibayashi, Yoshiki Shikano, Yutaka An, Toshu Fujiwara, Masazumi |
| contents | Optically accessible spin-active nanomaterials are promising as quantum nanosensors for probing biological samples. However, achieving bioimaging-level brightness and high-quality spin properties for these materials is challenging and hinders their application in quantum biosensing. Here, we demonstrate ultrabright fluorescent nanodiamonds (NDs) containing 0.6-1.3-ppm nitrogen-vacancy (NV) centers by spin-environment engineering via enriching spin-less 12C-carbon isotopes and reducing substitutional nitrogen spin impurities. The NDs, readily introduced into cultured cells, exhibited substantially narrow optically detected magnetic resonance (ODMR) spectra, requiring 16-times less microwave excitation power to give an ODMR depth comparable to that of conventional type-Ib NDs. They show average spin-relaxation times of T1 = 0.68 ms and T_2 = 1.6 us (1.6 ms and 2.7 us maximum) that were 5- and 11-fold longer than those of type-Ib, respectively. The bulk-like NV spin properties and bright fluorescence demonstrated in this study significantly improve the sensitivity of ND-based quantum sensors for biological applications. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2312_17603 |
| institution | arXiv |
| publishDate | 2023 |
| record_format | arxiv |
| spellingShingle | Quantum-grade nanodiamonds for ultrabright spin detection in live cells Oshimi, Keisuke Nakashima, Hiromu Mandić, Sara Kobayashi, Hina Teramoto, Minori Tsuji, Hirokazu Nishibayashi, Yoshiki Shikano, Yutaka An, Toshu Fujiwara, Masazumi Applied Physics Quantum Physics Optically accessible spin-active nanomaterials are promising as quantum nanosensors for probing biological samples. However, achieving bioimaging-level brightness and high-quality spin properties for these materials is challenging and hinders their application in quantum biosensing. Here, we demonstrate ultrabright fluorescent nanodiamonds (NDs) containing 0.6-1.3-ppm nitrogen-vacancy (NV) centers by spin-environment engineering via enriching spin-less 12C-carbon isotopes and reducing substitutional nitrogen spin impurities. The NDs, readily introduced into cultured cells, exhibited substantially narrow optically detected magnetic resonance (ODMR) spectra, requiring 16-times less microwave excitation power to give an ODMR depth comparable to that of conventional type-Ib NDs. They show average spin-relaxation times of T1 = 0.68 ms and T_2 = 1.6 us (1.6 ms and 2.7 us maximum) that were 5- and 11-fold longer than those of type-Ib, respectively. The bulk-like NV spin properties and bright fluorescence demonstrated in this study significantly improve the sensitivity of ND-based quantum sensors for biological applications. |
| title | Quantum-grade nanodiamonds for ultrabright spin detection in live cells |
| topic | Applied Physics Quantum Physics |
| url | https://arxiv.org/abs/2312.17603 |