Impact of maternal high fat on neurovascular unit of adult offspring
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arXiv
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| Autores principales: | , , , , , , , , |
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| Formato: | Preprint |
| Publicado: |
2024
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| _version_ | 1866929204503773184 |
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| author | Hawkes, Cheryl A. Goss, Victoria Zotova, Elina Monfort, Tual Postle, Anthony Mahajan, Sumeet Nicoll, James A. R. Weller, Roy O. Carare, Roxana O. |
| author_facet | Hawkes, Cheryl A. Goss, Victoria Zotova, Elina Monfort, Tual Postle, Anthony Mahajan, Sumeet Nicoll, James A. R. Weller, Roy O. Carare, Roxana O. |
| contents | Maternal obesity is associated with increased risk of diabetes, cardiovascular disease and hypertension in adult offspring. Midlife hypercholesterolemia and hypertension are risk factors for Alzheimer's disease, suggesting that the ageing brain may be impacted by early life environment. We found that exposure to a high fat diet during gestation and lactation induced changes in multiple components of the neurovascular unit, including a downregulation in apolipoprotein E and fibronectin, an upregulation in markers of astrocytes and perivascular macrophages and altered blood vessel morphology in the brains of adult mice. Feeding of high fat diet after weaning increased lipid droplets in the brain and influenced the fatty acid composition of phosphatidylcholine and phosphatidylethanolamine species, but did not affect the neurovascular unit. Sustained high fat diet over the entire lifespan resulted in additional decreases in levels of pericytes and collagen IV, changes in phospholipid composition and impaired perivascular clearance of Beta-amyloid (A-Beta) from the brain. In humans, vascular A-Beta load was significantly increased in the brains of aged individuals with a history of hypercholesterolemia. These results support a critical role for early dietary influence on the brain vasculature across the lifespan, with consequences for the development of age-related cerebrovascular and neurodegenerative diseases. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2401_04602 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Impact of maternal high fat on neurovascular unit of adult offspring Hawkes, Cheryl A. Goss, Victoria Zotova, Elina Monfort, Tual Postle, Anthony Mahajan, Sumeet Nicoll, James A. R. Weller, Roy O. Carare, Roxana O. Tissues and Organs 14J60 F.2.2 Maternal obesity is associated with increased risk of diabetes, cardiovascular disease and hypertension in adult offspring. Midlife hypercholesterolemia and hypertension are risk factors for Alzheimer's disease, suggesting that the ageing brain may be impacted by early life environment. We found that exposure to a high fat diet during gestation and lactation induced changes in multiple components of the neurovascular unit, including a downregulation in apolipoprotein E and fibronectin, an upregulation in markers of astrocytes and perivascular macrophages and altered blood vessel morphology in the brains of adult mice. Feeding of high fat diet after weaning increased lipid droplets in the brain and influenced the fatty acid composition of phosphatidylcholine and phosphatidylethanolamine species, but did not affect the neurovascular unit. Sustained high fat diet over the entire lifespan resulted in additional decreases in levels of pericytes and collagen IV, changes in phospholipid composition and impaired perivascular clearance of Beta-amyloid (A-Beta) from the brain. In humans, vascular A-Beta load was significantly increased in the brains of aged individuals with a history of hypercholesterolemia. These results support a critical role for early dietary influence on the brain vasculature across the lifespan, with consequences for the development of age-related cerebrovascular and neurodegenerative diseases. |
| title | Impact of maternal high fat on neurovascular unit of adult offspring |
| topic | Tissues and Organs 14J60 F.2.2 |
| url | https://arxiv.org/abs/2401.04602 |