Biofilms as poroelastic materials
Fuente:
arXiv
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| Autori principali: | , , |
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| Natura: | Preprint |
| Pubblicazione: |
2024
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| _version_ | 1866916091455864832 |
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| author | Carpio, Ana Cebrian, Elena Vidal, Perfecto |
| author_facet | Carpio, Ana Cebrian, Elena Vidal, Perfecto |
| contents | Biofilms are bacterial aggregates encased in a self-produced polymeric matrix which attach to moist surfaces and are extremely resistant to chemicals and antibiotics. Recent experiments show that their structure is defined by the interplay of elastic deformations and liquid transport within the biofilm, in response to the cellular activity and the interaction with the surrounding environment. We propose a poroelastic model for elastic deformation and liquid transport in three dimensional biofilms spreading on agar surfaces. The motion of the boundaries can be described by the combined use of Von Karman type approximations for the agar/biofilm interface and thin film approximations for the biofilm/air interface. Bacterial activity informs the macroscopic continuous model through source terms and residual stresses, either phenomenological or derived from microscopic models. We present a procedure to estimate the structure of such residual stresses, based on a simple cellular automata description of bacterial activity. Inspired by image processing, we show that a filtering strategy effectively smooths out the rough tensors provided by the stochastic cellular automata rules, allowing us to insert them in the macroscopic model without numerical instability. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2401_07060 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Biofilms as poroelastic materials Carpio, Ana Cebrian, Elena Vidal, Perfecto Soft Condensed Matter Numerical Analysis Analysis of PDEs Biological Physics Cell Behavior Biofilms are bacterial aggregates encased in a self-produced polymeric matrix which attach to moist surfaces and are extremely resistant to chemicals and antibiotics. Recent experiments show that their structure is defined by the interplay of elastic deformations and liquid transport within the biofilm, in response to the cellular activity and the interaction with the surrounding environment. We propose a poroelastic model for elastic deformation and liquid transport in three dimensional biofilms spreading on agar surfaces. The motion of the boundaries can be described by the combined use of Von Karman type approximations for the agar/biofilm interface and thin film approximations for the biofilm/air interface. Bacterial activity informs the macroscopic continuous model through source terms and residual stresses, either phenomenological or derived from microscopic models. We present a procedure to estimate the structure of such residual stresses, based on a simple cellular automata description of bacterial activity. Inspired by image processing, we show that a filtering strategy effectively smooths out the rough tensors provided by the stochastic cellular automata rules, allowing us to insert them in the macroscopic model without numerical instability. |
| title | Biofilms as poroelastic materials |
| topic | Soft Condensed Matter Numerical Analysis Analysis of PDEs Biological Physics Cell Behavior |
| url | https://arxiv.org/abs/2401.07060 |