Sources of HIV infections among MSM with a migration background: a viral phylogenetic case study in Amsterdam, the Netherlands
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arXiv
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Preprint |
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2024
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| author | Blenkinsop, Alexandra Pantazis, Nikos Kostaki, Evangelia Georgia Sofocleous, Lysandros van Sighem, Ard Bezemer, Daniela van de Laar, Thijs van der Valk, Marc Reiss, Peter de Bree, Godelieve Ratmann, Oliver |
| author_facet | Blenkinsop, Alexandra Pantazis, Nikos Kostaki, Evangelia Georgia Sofocleous, Lysandros van Sighem, Ard Bezemer, Daniela van de Laar, Thijs van der Valk, Marc Reiss, Peter de Bree, Godelieve Ratmann, Oliver |
| contents | Background: Men and women with a migration background comprise an increasing proportion of incident HIV cases across Western Europe. Several studies indicate a substantial proportion acquire HIV post-migration.
Methods: We used partial HIV consensus sequences with linked demographic and clinical data from the opt-out ATHENA cohort of people with HIV in the Netherlands to quantify population-level sources of transmission to Dutch-born and foreign-born Amsterdam men who have sex with men (MSM) between 2010-2021. We identified phylogenetically and epidemiologically possible transmission pairs in local transmission chains and interpreted these in the context of estimated infection dates, quantifying transmission dynamics between sub-populations by world region of birth.
Results: We estimate the majority of Amsterdam MSM who acquired their infection locally had a Dutch-born Amsterdam MSM source (56% [53-58%]). Dutch-born MSM were the predominant source population of infections among almost all foreign-born Amsterdam MSM sub-populations. Stratifying by two-year intervals indicated shifts in transmission dynamics, with a majority of infections originating from foreign-born MSM since 2018, although uncertainty ranges remained wide.
Conclusions: In the context of declining HIV incidence among Amsterdam MSM, our data suggest whilst native-born MSM have predominantly driven transmissions in 2010-2021, the contribution from foreign-born MSM living in Amsterdam is increasing. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2401_08308 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Sources of HIV infections among MSM with a migration background: a viral phylogenetic case study in Amsterdam, the Netherlands Blenkinsop, Alexandra Pantazis, Nikos Kostaki, Evangelia Georgia Sofocleous, Lysandros van Sighem, Ard Bezemer, Daniela van de Laar, Thijs van der Valk, Marc Reiss, Peter de Bree, Godelieve Ratmann, Oliver Populations and Evolution Background: Men and women with a migration background comprise an increasing proportion of incident HIV cases across Western Europe. Several studies indicate a substantial proportion acquire HIV post-migration. Methods: We used partial HIV consensus sequences with linked demographic and clinical data from the opt-out ATHENA cohort of people with HIV in the Netherlands to quantify population-level sources of transmission to Dutch-born and foreign-born Amsterdam men who have sex with men (MSM) between 2010-2021. We identified phylogenetically and epidemiologically possible transmission pairs in local transmission chains and interpreted these in the context of estimated infection dates, quantifying transmission dynamics between sub-populations by world region of birth. Results: We estimate the majority of Amsterdam MSM who acquired their infection locally had a Dutch-born Amsterdam MSM source (56% [53-58%]). Dutch-born MSM were the predominant source population of infections among almost all foreign-born Amsterdam MSM sub-populations. Stratifying by two-year intervals indicated shifts in transmission dynamics, with a majority of infections originating from foreign-born MSM since 2018, although uncertainty ranges remained wide. Conclusions: In the context of declining HIV incidence among Amsterdam MSM, our data suggest whilst native-born MSM have predominantly driven transmissions in 2010-2021, the contribution from foreign-born MSM living in Amsterdam is increasing. |
| title | Sources of HIV infections among MSM with a migration background: a viral phylogenetic case study in Amsterdam, the Netherlands |
| topic | Populations and Evolution |
| url | https://arxiv.org/abs/2401.08308 |