Interaction of surfactant and protein at the o/w interface and its effect on colloidal and biological properties of polymeric nanocarriers
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arXiv
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| Autori principali: | , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2024
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| _version_ | 1866911760425943040 |
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| author | Del Castillo-Santaella, Teresa Garcia, Jose Manuel Peula Maldonado-Valderrama, Julia Jodar-Reyes, Ana Belen |
| author_facet | Del Castillo-Santaella, Teresa Garcia, Jose Manuel Peula Maldonado-Valderrama, Julia Jodar-Reyes, Ana Belen |
| contents | The use of polymer-based surfactants in the double-emulsion (water/oil/water, W/O/W) solvent-evaporation technique is becoming a widespread strategy for preparing biocompatible and biodegradable polymeric nanoparticles (NPs) loaded with biomolecules of interest in biomedicine, or biotechnology. This approach enhances the stability of the NPs, reduces their size and recognition by the mononuclear phagocytic system, and protects the encapsulated biomolecule against losing biological activity. Different protocols to add the surfactant during the synthesis lead to different NP colloidal properties and biological activity. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2401_10145 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Interaction of surfactant and protein at the o/w interface and its effect on colloidal and biological properties of polymeric nanocarriers Del Castillo-Santaella, Teresa Garcia, Jose Manuel Peula Maldonado-Valderrama, Julia Jodar-Reyes, Ana Belen Soft Condensed Matter Applied Physics The use of polymer-based surfactants in the double-emulsion (water/oil/water, W/O/W) solvent-evaporation technique is becoming a widespread strategy for preparing biocompatible and biodegradable polymeric nanoparticles (NPs) loaded with biomolecules of interest in biomedicine, or biotechnology. This approach enhances the stability of the NPs, reduces their size and recognition by the mononuclear phagocytic system, and protects the encapsulated biomolecule against losing biological activity. Different protocols to add the surfactant during the synthesis lead to different NP colloidal properties and biological activity. |
| title | Interaction of surfactant and protein at the o/w interface and its effect on colloidal and biological properties of polymeric nanocarriers |
| topic | Soft Condensed Matter Applied Physics |
| url | https://arxiv.org/abs/2401.10145 |