Diffusion of intrinsically disordered proteins within viscoelastic membraneless droplets
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arXiv
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| Autori principali: | , , , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2024
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| _version_ | 1866908623439921152 |
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| author | Watanabe, Fuga Akimoto, Takuma Best, Robert B. Lindorff-Larsen, Kresten Metzler, Ralf Yamamoto, Eiji |
| author_facet | Watanabe, Fuga Akimoto, Takuma Best, Robert B. Lindorff-Larsen, Kresten Metzler, Ralf Yamamoto, Eiji |
| contents | In living cells, intrinsically disordered proteins (IDPs), such as FUS and DDX4, undergo phase separation, forming biomolecular condensates. Using molecular dynamics simulations, we investigate their behavior in their respective homogenous droplets. We find that the proteins exhibit transient subdiffusion due to the viscoelastic nature and confinement effects in the droplets. The conformation and the instantaneous diffusivity of the proteins significantly vary between the interior and the interface of the droplet, resulting in non-Gaussianity in the displacement distributions. This study highlights key aspects of IDP behavior in biomolecular condensates. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2401_10438 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Diffusion of intrinsically disordered proteins within viscoelastic membraneless droplets Watanabe, Fuga Akimoto, Takuma Best, Robert B. Lindorff-Larsen, Kresten Metzler, Ralf Yamamoto, Eiji Soft Condensed Matter Statistical Mechanics Biological Physics Computational Physics Biomolecules In living cells, intrinsically disordered proteins (IDPs), such as FUS and DDX4, undergo phase separation, forming biomolecular condensates. Using molecular dynamics simulations, we investigate their behavior in their respective homogenous droplets. We find that the proteins exhibit transient subdiffusion due to the viscoelastic nature and confinement effects in the droplets. The conformation and the instantaneous diffusivity of the proteins significantly vary between the interior and the interface of the droplet, resulting in non-Gaussianity in the displacement distributions. This study highlights key aspects of IDP behavior in biomolecular condensates. |
| title | Diffusion of intrinsically disordered proteins within viscoelastic membraneless droplets |
| topic | Soft Condensed Matter Statistical Mechanics Biological Physics Computational Physics Biomolecules |
| url | https://arxiv.org/abs/2401.10438 |