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Micro and Nano 3D investigation of complex gut alterations-dementia interplay

Fuente: arXiv

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Bibliographic Details
Main Authors:	Palermo, F., Marrocco, N., Dacomo, L., Grisafi, E., Musella, M., Moresi, V., Sanna, A., Massimi, L., Bukreeva, I., Junemann, O., Viola, I., Eckermann, M., Cloetens, P., Weitkamp, T., Gigli, G., Logroscino, G., de Rosbo, N. Kerlero, Balducci, C., Cedola, A.
Format:	Preprint
Published:	2024
Subjects:	Applied Physics
Online Access:	Acceder al recurso
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author	Palermo, F. Marrocco, N. Dacomo, L. Grisafi, E. Musella, M. Moresi, V. Sanna, A. Massimi, L. Bukreeva, I. Junemann, O. Viola, I. Eckermann, M. Cloetens, P. Weitkamp, T. Gigli, G. Logroscino, G. de Rosbo, N. Kerlero Balducci, C. Cedola, A.
author_facet	Palermo, F. Marrocco, N. Dacomo, L. Grisafi, E. Musella, M. Moresi, V. Sanna, A. Massimi, L. Bukreeva, I. Junemann, O. Viola, I. Eckermann, M. Cloetens, P. Weitkamp, T. Gigli, G. Logroscino, G. de Rosbo, N. Kerlero Balducci, C. Cedola, A.
contents	Alzheimer's disease (AD), a debilitating neurodegenerative disorder, remains one of the foremost public health challenges of our time. Despite decades of research, its etiology largely remains enigmatic. Recently, attention has turned to the gut-brain axis, a complex network of communication between the gastrointestinal tract and the brain, as a potential player in the pathogenesis of AD. Here we exploited X-ray Phase Contrast Tomography to provide an in-depth analysis of the link between the gut condition and AD, exploring gut anatomy and structure in murine models. We conducted a comprehensive analysis by comparing the outcomes in various mouse models of cognitive impairment, including AD, frail mice, and frontotemporal dementia (FTD) affected mice. We discovered an association between substantial changes in the gut structure and the presence of amyloid-beta (A\b{eta}) in the brain. We found that the most important gut alterations are related to A\b{eta} occurrence in the brain. In particular, we investigated the gut morphology, the distribution of enteric micro-processes and neurons in the ileum. Understanding the intricate interplay between gut condition and dementia may open new avenues for early AD diagnosis and treatment offering hope for a future where these diseases may be more effectively addressed.
format	Preprint
id	arxiv_https___arxiv_org_abs_2401_14139
institution	arXiv
publishDate	2024
record_format	arxiv
spellingShingle	Micro and Nano 3D investigation of complex gut alterations-dementia interplay Palermo, F. Marrocco, N. Dacomo, L. Grisafi, E. Musella, M. Moresi, V. Sanna, A. Massimi, L. Bukreeva, I. Junemann, O. Viola, I. Eckermann, M. Cloetens, P. Weitkamp, T. Gigli, G. Logroscino, G. de Rosbo, N. Kerlero Balducci, C. Cedola, A. Applied Physics Alzheimer's disease (AD), a debilitating neurodegenerative disorder, remains one of the foremost public health challenges of our time. Despite decades of research, its etiology largely remains enigmatic. Recently, attention has turned to the gut-brain axis, a complex network of communication between the gastrointestinal tract and the brain, as a potential player in the pathogenesis of AD. Here we exploited X-ray Phase Contrast Tomography to provide an in-depth analysis of the link between the gut condition and AD, exploring gut anatomy and structure in murine models. We conducted a comprehensive analysis by comparing the outcomes in various mouse models of cognitive impairment, including AD, frail mice, and frontotemporal dementia (FTD) affected mice. We discovered an association between substantial changes in the gut structure and the presence of amyloid-beta (A\b{eta}) in the brain. We found that the most important gut alterations are related to A\b{eta} occurrence in the brain. In particular, we investigated the gut morphology, the distribution of enteric micro-processes and neurons in the ileum. Understanding the intricate interplay between gut condition and dementia may open new avenues for early AD diagnosis and treatment offering hope for a future where these diseases may be more effectively addressed.
title	Micro and Nano 3D investigation of complex gut alterations-dementia interplay
topic	Applied Physics
url	https://arxiv.org/abs/2401.14139