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| Main Authors: | , , , , , , |
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| Format: | Preprint |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2401.14172 |
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| _version_ | 1866914837179662336 |
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| author | Givarian, Mahshid Moztarzadeh, Fathollah Ghaffari, Maryam Bahmanpour, AmirHossein Mollazadeh-Bajestani, Maryam Mokhtari-Dizaji, Manijhe Mehradnia, Fatemeh |
| author_facet | Givarian, Mahshid Moztarzadeh, Fathollah Ghaffari, Maryam Bahmanpour, AmirHossein Mollazadeh-Bajestani, Maryam Mokhtari-Dizaji, Manijhe Mehradnia, Fatemeh |
| contents | Background: The development of smart nanocarriers that enable controlled drug release in response to internal and external triggers is an emerging approach for targeted therapy. This study focused on designing pH-sensitive, ultrasound-responsive gelatin/perfluorohexane (PFH) nanodroplets loaded with berberine chloride as a model drug. Results:The nanodroplets were prepared using an emulsion technique and optimized by varying process parameters like homogenization rate, polymer concentration, surfactant, drug, and perfluorocarbon content. The optimal formulation yielded nanodroplets with a particle size of 281.7 nm, a drug encapsulation efficiency of 66.8+- 1.7%, and a passive drug release of 15.4+- 0.2% within 24 hours. Characterization confirmed successful encapsulation and pH-responsive behavior. Ultrasound stimulation significantly enhanced drug release, with 150 kHz being more effective than 1 MHz in triggering acoustic droplet vaporization while minimizing heat generation. After 10 minutes of radiation, the optimal formulation showed 89.4% cumulative drug release. The nanodroplets displayed stability over one month at 4°C. Conclusions: Overall, the dual-triggered nanodroplets demonstrate excellent potential for controlled delivery and targeted release of berberine chloride. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2401_14172 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Dual-trigger release of berberine chloride from the Gelatin/Perfluorohexane core-shell structure Givarian, Mahshid Moztarzadeh, Fathollah Ghaffari, Maryam Bahmanpour, AmirHossein Mollazadeh-Bajestani, Maryam Mokhtari-Dizaji, Manijhe Mehradnia, Fatemeh Quantitative Methods Background: The development of smart nanocarriers that enable controlled drug release in response to internal and external triggers is an emerging approach for targeted therapy. This study focused on designing pH-sensitive, ultrasound-responsive gelatin/perfluorohexane (PFH) nanodroplets loaded with berberine chloride as a model drug. Results:The nanodroplets were prepared using an emulsion technique and optimized by varying process parameters like homogenization rate, polymer concentration, surfactant, drug, and perfluorocarbon content. The optimal formulation yielded nanodroplets with a particle size of 281.7 nm, a drug encapsulation efficiency of 66.8+- 1.7%, and a passive drug release of 15.4+- 0.2% within 24 hours. Characterization confirmed successful encapsulation and pH-responsive behavior. Ultrasound stimulation significantly enhanced drug release, with 150 kHz being more effective than 1 MHz in triggering acoustic droplet vaporization while minimizing heat generation. After 10 minutes of radiation, the optimal formulation showed 89.4% cumulative drug release. The nanodroplets displayed stability over one month at 4°C. Conclusions: Overall, the dual-triggered nanodroplets demonstrate excellent potential for controlled delivery and targeted release of berberine chloride. |
| title | Dual-trigger release of berberine chloride from the Gelatin/Perfluorohexane core-shell structure |
| topic | Quantitative Methods |
| url | https://arxiv.org/abs/2401.14172 |