Graphene field-effect transistors for sensing ion-channel coupled receptors: towards biohybrid nanoelectronics for chemical detection
Fuente:
arXiv
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Preprint |
| Veröffentlicht: |
2024
|
| Schlagworte: | |
| Online-Zugang: | |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| _version_ | 1866913225541419008 |
|---|---|
| author | Terral, Océane Audic, Guillaume Claudel, Arnaud Magnat, Justine Dupont, Aurélie Moreau, Christophe J. Delacour, Cécile |
| author_facet | Terral, Océane Audic, Guillaume Claudel, Arnaud Magnat, Justine Dupont, Aurélie Moreau, Christophe J. Delacour, Cécile |
| contents | Graphene field effect transistors (G-FETs) have appeared as suitable candidates for sensing charges and have thus attracted large interest for ion and chemical detections. In particular, their high sensitivity, chemical robustness, transparency and bendability offer a unique combination for interfacing living and soft matters. Here we have demonstrated their ability to sense targeted biomolecules, by combining them with ion channels-coupled receptors (ICCRs). These receptors have been naturally or artificially expressed within living cell membranes to generate ion fluxes in presence of chemicals of interest. Here, we have successfully combined those biosensors with G-FET array which converts the bio-activation of the ICCRs into readable electronic signals. This hybrid bioelectronic device leverages the advantages of the biological receptor and the graphene field effect transistor enabling the selective detection of biomolecules, which is a current shortcoming of electronic sensors. Additionally, the G-FET allows to discriminate the polarity of the ion fluxes which otherwise remains hidden from conventional electrophysiological recordings. The multisite recording ability offered by the G-FET array rises numerous possibilities for multiscale sensing and high throughput screening of cellular solutions or analytes, which is of both fundamental and applied interests in health and environment monitoring. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2402_04378 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Graphene field-effect transistors for sensing ion-channel coupled receptors: towards biohybrid nanoelectronics for chemical detection Terral, Océane Audic, Guillaume Claudel, Arnaud Magnat, Justine Dupont, Aurélie Moreau, Christophe J. Delacour, Cécile Mesoscale and Nanoscale Physics Graphene field effect transistors (G-FETs) have appeared as suitable candidates for sensing charges and have thus attracted large interest for ion and chemical detections. In particular, their high sensitivity, chemical robustness, transparency and bendability offer a unique combination for interfacing living and soft matters. Here we have demonstrated their ability to sense targeted biomolecules, by combining them with ion channels-coupled receptors (ICCRs). These receptors have been naturally or artificially expressed within living cell membranes to generate ion fluxes in presence of chemicals of interest. Here, we have successfully combined those biosensors with G-FET array which converts the bio-activation of the ICCRs into readable electronic signals. This hybrid bioelectronic device leverages the advantages of the biological receptor and the graphene field effect transistor enabling the selective detection of biomolecules, which is a current shortcoming of electronic sensors. Additionally, the G-FET allows to discriminate the polarity of the ion fluxes which otherwise remains hidden from conventional electrophysiological recordings. The multisite recording ability offered by the G-FET array rises numerous possibilities for multiscale sensing and high throughput screening of cellular solutions or analytes, which is of both fundamental and applied interests in health and environment monitoring. |
| title | Graphene field-effect transistors for sensing ion-channel coupled receptors: towards biohybrid nanoelectronics for chemical detection |
| topic | Mesoscale and Nanoscale Physics |
| url | https://arxiv.org/abs/2402.04378 |