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| Main Authors: | , , , , , |
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| Format: | Preprint |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://arxiv.org/abs/2402.06749 |
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| _version_ | 1866910325752725504 |
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| author | Nozdriukhin, Daniil Lyu, Shuxin Bonvin, Jerome Reiss, Michael Razansky, Daniel Dean-Ben, Xose Luis |
| author_facet | Nozdriukhin, Daniil Lyu, Shuxin Bonvin, Jerome Reiss, Michael Razansky, Daniel Dean-Ben, Xose Luis |
| contents | Efficient drug delivery is a major challenge in modern medicine and pharmaceutical research. Micrometer-scale robots have recently been proposed as a promising venue to amplify precision of drug administration. Remotely controlled microrobots sufficiently small to navigate through microvascular networks can reach any part of the human body, yet real-time tracking is crucial for providing precise guidance and verifying successful arrival at the target. In vivo deep-tissue monitoring of individual microrobots is currently hampered by the lack of sensitivity and/or spatio-temporal resolution of commonly used clinical imaging modalities. We synthesized biocompatible and biodegradable copper phosphate micro-flowers loaded with indocyanine green and iron oxide nanoparticles to enable in vivo individual detection with localization optoacoustic tomography. We demonstrate magnetic actuation and optoacoustic tracking of these decorated micro-flowers at a per-particle level. Functional super-resolution imaging achieved via tracking intravenously injected particles provides a means of identifying microvascular targets and quantifying blood flow, while the versatile carrying capacity can be further exploited for transporting multiple types of drug formulations. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2402_06749 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Copper phosphate micro-flowers coated with indocyanine green and iron oxide nanoparticles for in vivo localization optoacoustic tomography and magnetic actuation Nozdriukhin, Daniil Lyu, Shuxin Bonvin, Jerome Reiss, Michael Razansky, Daniel Dean-Ben, Xose Luis Optics Biological Physics Medical Physics Efficient drug delivery is a major challenge in modern medicine and pharmaceutical research. Micrometer-scale robots have recently been proposed as a promising venue to amplify precision of drug administration. Remotely controlled microrobots sufficiently small to navigate through microvascular networks can reach any part of the human body, yet real-time tracking is crucial for providing precise guidance and verifying successful arrival at the target. In vivo deep-tissue monitoring of individual microrobots is currently hampered by the lack of sensitivity and/or spatio-temporal resolution of commonly used clinical imaging modalities. We synthesized biocompatible and biodegradable copper phosphate micro-flowers loaded with indocyanine green and iron oxide nanoparticles to enable in vivo individual detection with localization optoacoustic tomography. We demonstrate magnetic actuation and optoacoustic tracking of these decorated micro-flowers at a per-particle level. Functional super-resolution imaging achieved via tracking intravenously injected particles provides a means of identifying microvascular targets and quantifying blood flow, while the versatile carrying capacity can be further exploited for transporting multiple types of drug formulations. |
| title | Copper phosphate micro-flowers coated with indocyanine green and iron oxide nanoparticles for in vivo localization optoacoustic tomography and magnetic actuation |
| topic | Optics Biological Physics Medical Physics |
| url | https://arxiv.org/abs/2402.06749 |