Criticality in the Luria-Delbrück model with an arbitrary mutation rate
Fuente:
arXiv
Salvato in:
| Autori principali: | , , |
|---|---|
| Natura: | Preprint |
| Pubblicazione: |
2024
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1866929250188132352 |
|---|---|
| author | Pan, Deng Lin, Jie Amir, Ariel |
| author_facet | Pan, Deng Lin, Jie Amir, Ariel |
| contents | The Luria-Delbrück model is a classic model of population dynamics with random mutations, that has been used historically to prove that random mutations drive evolution. In typical scenarios, the relevant mutation rate is exceedingly small, and mutants are counted only at the final time point. Here, inspired by recent experiments on DNA repair, we study a mathematical model that is formally equivalent to the Luria-Delbrück setup, with the repair rate $p$ playing the role of mutation rate, albeit taking on large values, of order unity per cell division. We find that although at large times the fraction of repaired cells approaches one, the variance of the number of repaired cells undergoes a phase transition: when $p>1/2$ the variance decreases with time, but, intriguingly, for $p<1/2$ even though the fraction of repaired cells approaches 1, the variance in number of repaired cells increases with time. Analyzing DNA-repair experiments, we find that in order to explain the data the model should also take into account the probability of a successful repair process once it is initiated. Taken together, our work shows how the study of variability can lead to surprising phase-transitions as well as provide biological insights into the process of DNA-repair. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2402_13339 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Criticality in the Luria-Delbrück model with an arbitrary mutation rate Pan, Deng Lin, Jie Amir, Ariel Biological Physics Populations and Evolution The Luria-Delbrück model is a classic model of population dynamics with random mutations, that has been used historically to prove that random mutations drive evolution. In typical scenarios, the relevant mutation rate is exceedingly small, and mutants are counted only at the final time point. Here, inspired by recent experiments on DNA repair, we study a mathematical model that is formally equivalent to the Luria-Delbrück setup, with the repair rate $p$ playing the role of mutation rate, albeit taking on large values, of order unity per cell division. We find that although at large times the fraction of repaired cells approaches one, the variance of the number of repaired cells undergoes a phase transition: when $p>1/2$ the variance decreases with time, but, intriguingly, for $p<1/2$ even though the fraction of repaired cells approaches 1, the variance in number of repaired cells increases with time. Analyzing DNA-repair experiments, we find that in order to explain the data the model should also take into account the probability of a successful repair process once it is initiated. Taken together, our work shows how the study of variability can lead to surprising phase-transitions as well as provide biological insights into the process of DNA-repair. |
| title | Criticality in the Luria-Delbrück model with an arbitrary mutation rate |
| topic | Biological Physics Populations and Evolution |
| url | https://arxiv.org/abs/2402.13339 |