Methylation Operation Wizard (MeOW): Identification of differentially methylated regions in long-read sequencing data
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arXiv
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| Format: | Preprint |
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2024
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| _version_ | 1866914692969005056 |
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| author | Zalusky, Miranda PG Miller, Danny E |
| author_facet | Zalusky, Miranda PG Miller, Danny E |
| contents | Long-read sequencing (LRS) is able to simultaneously capture information about both DNA sequence and modifications, such as CpG methylation in a single sequencing experiment. Here we present Methylation Operation Wizard (MeOW), a program to identify and prioritize differentially methylated regions (DMRs) genome-wide using LRS data. MeOW can be run using either a file containing counts of per-nucleotide methylated CpG sites or with a bam file containing modified base tags. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2402_17182 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Methylation Operation Wizard (MeOW): Identification of differentially methylated regions in long-read sequencing data Zalusky, Miranda PG Miller, Danny E Genomics Quantitative Methods Long-read sequencing (LRS) is able to simultaneously capture information about both DNA sequence and modifications, such as CpG methylation in a single sequencing experiment. Here we present Methylation Operation Wizard (MeOW), a program to identify and prioritize differentially methylated regions (DMRs) genome-wide using LRS data. MeOW can be run using either a file containing counts of per-nucleotide methylated CpG sites or with a bam file containing modified base tags. |
| title | Methylation Operation Wizard (MeOW): Identification of differentially methylated regions in long-read sequencing data |
| topic | Genomics Quantitative Methods |
| url | https://arxiv.org/abs/2402.17182 |