Non Equilibrium Transitions in a Polymer Replication Ensemble
Fuente:
arXiv
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| Autori principali: | , , , |
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| Natura: | Preprint |
| Pubblicazione: |
2024
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| Soggetti: | |
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| _version_ | 1866909494919823360 |
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| author | Genthon, Arthur Modes, Carl D. Jülicher, Frank Grill, Stephan W. |
| author_facet | Genthon, Arthur Modes, Carl D. Jülicher, Frank Grill, Stephan W. |
| contents | The fuel-driven process of replication in living systems generates distributions of copied entities with varying degrees of copying accuracy. Here we introduce a thermodynamically consistent ensemble for investigating universal population features of replicating systems. In the context of copolymer copying, coarse-graining over molecular details, we establish a phase diagram of copying accuracy. We discover sharp non-equilibrium transitions between populations of random and accurate copies. Maintaining a population of accurate copies requires a minimum energy expenditure that depends on the configurational entropy of copolymer sequences. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2403_05665 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Non Equilibrium Transitions in a Polymer Replication Ensemble Genthon, Arthur Modes, Carl D. Jülicher, Frank Grill, Stephan W. Statistical Mechanics Biological Physics The fuel-driven process of replication in living systems generates distributions of copied entities with varying degrees of copying accuracy. Here we introduce a thermodynamically consistent ensemble for investigating universal population features of replicating systems. In the context of copolymer copying, coarse-graining over molecular details, we establish a phase diagram of copying accuracy. We discover sharp non-equilibrium transitions between populations of random and accurate copies. Maintaining a population of accurate copies requires a minimum energy expenditure that depends on the configurational entropy of copolymer sequences. |
| title | Non Equilibrium Transitions in a Polymer Replication Ensemble |
| topic | Statistical Mechanics Biological Physics |
| url | https://arxiv.org/abs/2403.05665 |