An in-silico approach to meniscus tissue regeneration: Modeling, numerical simulation, and experimental analysis
Fuente:
arXiv
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Preprint |
| Published: |
2024
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866917053852549120 |
|---|---|
| author | Grosjean, Elise Keilmann, Alex Jäger, Henry Mohanan, Shimi Redenbach, Claudia Simeon, Bernd Surulescu, Christina de Roy, Luisa Seitz, Andreas Teixeira, Graciosa Dauner, Martin Linti, Carsten Schmidt, Günter |
| author_facet | Grosjean, Elise Keilmann, Alex Jäger, Henry Mohanan, Shimi Redenbach, Claudia Simeon, Bernd Surulescu, Christina de Roy, Luisa Seitz, Andreas Teixeira, Graciosa Dauner, Martin Linti, Carsten Schmidt, Günter |
| contents | We develop a model the dynamics of human mesenchymal stem cells (hMSCs) and chondrocytes evolving in a nonwoven polyethylene terephtalate (PET) scaffold impregnated with hyaluron and supplied with a differentiation medium. The scaffold and the cells are assumed to be contained in a bioreactor with fluid perfusion. The differentiation of hMSCs into chondrocytes favors the production of extracellular matrix (ECM) and is influenced by fluid stress. The model takes deformations of ECM and PET scaffold into account. The scaffold structure is explicitly included by statistical assessment of the fibre distribution from CT images. The effective macroscopic equations are obtained by appropriate upscaling from dynamics on lower (microscopic and mesoscopic) scales and feature in the motility terms an explicit cell diffusion tensor encoding the assessed anisotropic scaffold structure. Numerical simulations show its influence on the overall cell and tissue dynamics. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2403_05909 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | An in-silico approach to meniscus tissue regeneration: Modeling, numerical simulation, and experimental analysis Grosjean, Elise Keilmann, Alex Jäger, Henry Mohanan, Shimi Redenbach, Claudia Simeon, Bernd Surulescu, Christina de Roy, Luisa Seitz, Andreas Teixeira, Graciosa Dauner, Martin Linti, Carsten Schmidt, Günter Tissues and Organs Numerical Analysis Analysis of PDEs Cell Behavior Quantitative Methods We develop a model the dynamics of human mesenchymal stem cells (hMSCs) and chondrocytes evolving in a nonwoven polyethylene terephtalate (PET) scaffold impregnated with hyaluron and supplied with a differentiation medium. The scaffold and the cells are assumed to be contained in a bioreactor with fluid perfusion. The differentiation of hMSCs into chondrocytes favors the production of extracellular matrix (ECM) and is influenced by fluid stress. The model takes deformations of ECM and PET scaffold into account. The scaffold structure is explicitly included by statistical assessment of the fibre distribution from CT images. The effective macroscopic equations are obtained by appropriate upscaling from dynamics on lower (microscopic and mesoscopic) scales and feature in the motility terms an explicit cell diffusion tensor encoding the assessed anisotropic scaffold structure. Numerical simulations show its influence on the overall cell and tissue dynamics. |
| title | An in-silico approach to meniscus tissue regeneration: Modeling, numerical simulation, and experimental analysis |
| topic | Tissues and Organs Numerical Analysis Analysis of PDEs Cell Behavior Quantitative Methods |
| url | https://arxiv.org/abs/2403.05909 |