On the Echogenicity of Natural Starch-Based Blood Mimicking Fluids for Contrast Enhanced Ultrasound Imaging: Preliminary In-vitro Experiments
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| Format: | Preprint |
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2024
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| _version_ | 1866909233589518336 |
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| author | Kumar, V. Arun Madhavanunni, A. N. Nivetha, S. Panicker, Mahesh Raveendranatha |
| author_facet | Kumar, V. Arun Madhavanunni, A. N. Nivetha, S. Panicker, Mahesh Raveendranatha |
| contents | Natural starch-based blood-mimicking fluid (BMF) has been used as an alternative to commercially available BMFs for in-vitro Doppler investigations in low-resource settings. Most reported works in the literature have used corn starch-based BMF. Evaluation of other natural starches for potential BMF and their characterization have relatively been unexplored in the literature. To this end, this work investigates the echogenicity of corn-, potato-, tapioca-, and wheat starch-based BMFs prepared using a liquid base of pure water-glycerol mixture with three different starch concentrations (1%, 3%, and 5%). The experiments were performed by manually pumping the BMFs to a PolyVinyl alcohol (PVA) based flow phantom using a syringe and raw datasets were acquired using a Verasonics Vantage 128 Research Ultrasound System. Echogenicity was measured as the mean pixel intensity in a selected region of interest (ROI) in the beamformed image. Among the four natural starch-based BMFs, potato starch-based BMF showed the highest echogenicity and contrast with almost 13%, 14%, and 10% higher pixel intensities (dB) than that of the least echoic BMF with 1%, 3%, and 5% starch concentrations respectively. Moreover, the echogenicity of corn, tapioca, and wheat starch-based BMF was observed to be similar, and the results suggest that these BMFs with higher starch concentrations shall be employed for in-vitro contrast-enhanced ultrasound imaging. |
| format | Preprint |
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arxiv_https___arxiv_org_abs_2403_06237 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | On the Echogenicity of Natural Starch-Based Blood Mimicking Fluids for Contrast Enhanced Ultrasound Imaging: Preliminary In-vitro Experiments Kumar, V. Arun Madhavanunni, A. N. Nivetha, S. Panicker, Mahesh Raveendranatha Medical Physics Biological Physics Chemical Physics Natural starch-based blood-mimicking fluid (BMF) has been used as an alternative to commercially available BMFs for in-vitro Doppler investigations in low-resource settings. Most reported works in the literature have used corn starch-based BMF. Evaluation of other natural starches for potential BMF and their characterization have relatively been unexplored in the literature. To this end, this work investigates the echogenicity of corn-, potato-, tapioca-, and wheat starch-based BMFs prepared using a liquid base of pure water-glycerol mixture with three different starch concentrations (1%, 3%, and 5%). The experiments were performed by manually pumping the BMFs to a PolyVinyl alcohol (PVA) based flow phantom using a syringe and raw datasets were acquired using a Verasonics Vantage 128 Research Ultrasound System. Echogenicity was measured as the mean pixel intensity in a selected region of interest (ROI) in the beamformed image. Among the four natural starch-based BMFs, potato starch-based BMF showed the highest echogenicity and contrast with almost 13%, 14%, and 10% higher pixel intensities (dB) than that of the least echoic BMF with 1%, 3%, and 5% starch concentrations respectively. Moreover, the echogenicity of corn, tapioca, and wheat starch-based BMF was observed to be similar, and the results suggest that these BMFs with higher starch concentrations shall be employed for in-vitro contrast-enhanced ultrasound imaging. |
| title | On the Echogenicity of Natural Starch-Based Blood Mimicking Fluids for Contrast Enhanced Ultrasound Imaging: Preliminary In-vitro Experiments |
| topic | Medical Physics Biological Physics Chemical Physics |
| url | https://arxiv.org/abs/2403.06237 |