StainFuser: Controlling Diffusion for Faster Neural Style Transfer in Multi-Gigapixel Histology Images

Fuente: arXiv
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Auteurs principaux: Jewsbury, Robert, Wang, Ruoyu, Bhalerao, Abhir, Rajpoot, Nasir, Vu, Quoc Dang
Format: Preprint
Publié: 2024
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author Jewsbury, Robert
Wang, Ruoyu
Bhalerao, Abhir
Rajpoot, Nasir
Vu, Quoc Dang
author_facet Jewsbury, Robert
Wang, Ruoyu
Bhalerao, Abhir
Rajpoot, Nasir
Vu, Quoc Dang
contents Stain normalization algorithms aim to transform the color and intensity characteristics of a source multi-gigapixel histology image to match those of a target image, mitigating inconsistencies in the appearance of stains used to highlight cellular components in the images. We propose a new approach, StainFuser, which treats this problem as a style transfer task using a novel Conditional Latent Diffusion architecture, eliminating the need for handcrafted color components. With this method, we curate SPI-2M the largest stain normalization dataset to date of over 2 million histology images with neural style transfer for high-quality transformations. Trained on this data, StainFuser outperforms current state-of-the-art deep learning and handcrafted methods in terms of the quality of normalized images and in terms of downstream model performance on the CoNIC dataset.
format Preprint
id arxiv_https___arxiv_org_abs_2403_09302
institution arXiv
publishDate 2024
record_format arxiv
spellingShingle StainFuser: Controlling Diffusion for Faster Neural Style Transfer in Multi-Gigapixel Histology Images
Jewsbury, Robert
Wang, Ruoyu
Bhalerao, Abhir
Rajpoot, Nasir
Vu, Quoc Dang
Image and Video Processing
Computer Vision and Pattern Recognition
Machine Learning
Stain normalization algorithms aim to transform the color and intensity characteristics of a source multi-gigapixel histology image to match those of a target image, mitigating inconsistencies in the appearance of stains used to highlight cellular components in the images. We propose a new approach, StainFuser, which treats this problem as a style transfer task using a novel Conditional Latent Diffusion architecture, eliminating the need for handcrafted color components. With this method, we curate SPI-2M the largest stain normalization dataset to date of over 2 million histology images with neural style transfer for high-quality transformations. Trained on this data, StainFuser outperforms current state-of-the-art deep learning and handcrafted methods in terms of the quality of normalized images and in terms of downstream model performance on the CoNIC dataset.
title StainFuser: Controlling Diffusion for Faster Neural Style Transfer in Multi-Gigapixel Histology Images
topic Image and Video Processing
Computer Vision and Pattern Recognition
Machine Learning
url https://arxiv.org/abs/2403.09302