A hollow-core fiber based stand-alone multimodal (2-photon, 3-photon, SHG, THG) nonlinear flexible imaging endoscope
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arXiv
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| Format: | Preprint |
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2024
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| author | Septier, D. Brévalle-Wasilewski, G. Lefebvre, E. Kumar, N. Gajendra Wang, Y. J. Kaszas, A. Rigneault, H. Kudlinski, A. |
| author_facet | Septier, D. Brévalle-Wasilewski, G. Lefebvre, E. Kumar, N. Gajendra Wang, Y. J. Kaszas, A. Rigneault, H. Kudlinski, A. |
| contents | Multimodal nonlinear endoscopes have been a topic of intense research over the past two decades, enabling sub-cellular and label-free imaging in areas not reachable with table-top microscopes. They are sophisticated systems that can be implemented on an optical table in a lab environment, but they cannot be easily moved within or out of the lab. We present here a multimodal and flexible nonlinear endoscope system able to perform two photon excited fluorescence and second harmonic generation imaging with a stand-alone and moveable kart integrating a compact ultrashort laser source. In addition, the system can perform three photon excited fluorescence and third harmonic generation thanks to a delivery optical fiber used to deliver ultrashort pulses from massive and not movable laser systems into the stand-alone kart. The endoscopic fiber probes and delivery optical fibers are based on functionalized negative curvature hollow core fibers. The endoscope distal head has a diameter <2.2mm and can perform nonlinear imaging at max 10 frames/s over a field of view up to 600 $μ$m with a ~1 $μ$m spatial resolution. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2403_09391 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | A hollow-core fiber based stand-alone multimodal (2-photon, 3-photon, SHG, THG) nonlinear flexible imaging endoscope Septier, D. Brévalle-Wasilewski, G. Lefebvre, E. Kumar, N. Gajendra Wang, Y. J. Kaszas, A. Rigneault, H. Kudlinski, A. Optics Medical Physics Multimodal nonlinear endoscopes have been a topic of intense research over the past two decades, enabling sub-cellular and label-free imaging in areas not reachable with table-top microscopes. They are sophisticated systems that can be implemented on an optical table in a lab environment, but they cannot be easily moved within or out of the lab. We present here a multimodal and flexible nonlinear endoscope system able to perform two photon excited fluorescence and second harmonic generation imaging with a stand-alone and moveable kart integrating a compact ultrashort laser source. In addition, the system can perform three photon excited fluorescence and third harmonic generation thanks to a delivery optical fiber used to deliver ultrashort pulses from massive and not movable laser systems into the stand-alone kart. The endoscopic fiber probes and delivery optical fibers are based on functionalized negative curvature hollow core fibers. The endoscope distal head has a diameter <2.2mm and can perform nonlinear imaging at max 10 frames/s over a field of view up to 600 $μ$m with a ~1 $μ$m spatial resolution. |
| title | A hollow-core fiber based stand-alone multimodal (2-photon, 3-photon, SHG, THG) nonlinear flexible imaging endoscope |
| topic | Optics Medical Physics |
| url | https://arxiv.org/abs/2403.09391 |