Distribution-informed and wavelength-flexible data-driven photoacoustic oximetry
Fuente:
arXiv
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Preprint |
| Published: |
2024
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866917620171669504 |
|---|---|
| author | Gröhl, Janek Yeung, Kylie Gu, Kevin Else, Thomas R. Golinska, Monika Bunce, Ellie V. Hacker, Lina Bohndiek, Sarah E. |
| author_facet | Gröhl, Janek Yeung, Kylie Gu, Kevin Else, Thomas R. Golinska, Monika Bunce, Ellie V. Hacker, Lina Bohndiek, Sarah E. |
| contents | Significance: Photoacoustic imaging (PAI) promises to measure spatially-resolved blood oxygen saturation, but suffers from a lack of accurate and robust spectral unmixing methods to deliver on this promise. Accurate blood oxygenation estimation could have important clinical applications, from cancer detection to quantifying inflammation.
Aim: This study addresses the inflexibility of existing data-driven methods for estimating blood oxygenation in PAI by introducing a recurrent neural network architecture.
Approach: We created 25 simulated training dataset variations to assess neural network performance. We used a long short-term memory network to implement a wavelength-flexible network architecture and proposed the Jensen-Shannon divergence to predict the most suitable training dataset.
Results: The network architecture can handle arbitrary input wavelengths and outperforms linear unmixing and the previously proposed learned spectral decolouring method. Small changes in the training data significantly affect the accuracy of our method, but we find that the Jensen-Shannon divergence correlates with the estimation error and is thus suitable for predicting the most appropriate training datasets for any given application.
Conclusions: A flexible data-driven network architecture combined with the Jensen-Shannon Divergence to predict the best training data set provides a promising direction that might enable robust data-driven photoacoustic oximetry for clinical use cases. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2403_14863 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | Distribution-informed and wavelength-flexible data-driven photoacoustic oximetry Gröhl, Janek Yeung, Kylie Gu, Kevin Else, Thomas R. Golinska, Monika Bunce, Ellie V. Hacker, Lina Bohndiek, Sarah E. Medical Physics Computer Vision and Pattern Recognition Machine Learning F.2.1 Significance: Photoacoustic imaging (PAI) promises to measure spatially-resolved blood oxygen saturation, but suffers from a lack of accurate and robust spectral unmixing methods to deliver on this promise. Accurate blood oxygenation estimation could have important clinical applications, from cancer detection to quantifying inflammation. Aim: This study addresses the inflexibility of existing data-driven methods for estimating blood oxygenation in PAI by introducing a recurrent neural network architecture. Approach: We created 25 simulated training dataset variations to assess neural network performance. We used a long short-term memory network to implement a wavelength-flexible network architecture and proposed the Jensen-Shannon divergence to predict the most suitable training dataset. Results: The network architecture can handle arbitrary input wavelengths and outperforms linear unmixing and the previously proposed learned spectral decolouring method. Small changes in the training data significantly affect the accuracy of our method, but we find that the Jensen-Shannon divergence correlates with the estimation error and is thus suitable for predicting the most appropriate training datasets for any given application. Conclusions: A flexible data-driven network architecture combined with the Jensen-Shannon Divergence to predict the best training data set provides a promising direction that might enable robust data-driven photoacoustic oximetry for clinical use cases. |
| title | Distribution-informed and wavelength-flexible data-driven photoacoustic oximetry |
| topic | Medical Physics Computer Vision and Pattern Recognition Machine Learning F.2.1 |
| url | https://arxiv.org/abs/2403.14863 |