A story of viral co-infection, co-transmission and co-feeding in ticks: how to compute an invasion reproduction number
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arXiv
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2024
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| author | Belluccini, Giulia Lin, Qianying Williams, Bevelynn Lou, Yijun Vatansever, Zati López-García, Martín Lythe, Grant Leitner, Thomas Romero-Severson, Ethan Molina-París, Carmen |
| author_facet | Belluccini, Giulia Lin, Qianying Williams, Bevelynn Lou, Yijun Vatansever, Zati López-García, Martín Lythe, Grant Leitner, Thomas Romero-Severson, Ethan Molina-París, Carmen |
| contents | With a single circulating vector-borne virus, the basic reproduction number incorporates contributions from tick-to-tick (co-feeding), tick-to-host and host-to-tick transmission routes. With two different circulating vector-borne viral strains, resident and invasive, and under the assumption that co-feeding is the only transmission route in a tick population, the invasion reproduction number depends on whether the model system of ordinary differential equations possesses the property of neutrality. We show that a simple model, with two populations of ticks infected with one strain, resident or invasive, and one population of co-infected ticks, does not have Alizon's neutrality property. We present model alternatives that are capable of representing the invasion potential of a novel strain by including populations of ticks dually infected with the same strain. The invasion reproduction number is analysed with the next-generation method and via numerical simulations. |
| format | Preprint |
| id |
arxiv_https___arxiv_org_abs_2403_15282 |
| institution | arXiv |
| publishDate | 2024 |
| record_format | arxiv |
| spellingShingle | A story of viral co-infection, co-transmission and co-feeding in ticks: how to compute an invasion reproduction number Belluccini, Giulia Lin, Qianying Williams, Bevelynn Lou, Yijun Vatansever, Zati López-García, Martín Lythe, Grant Leitner, Thomas Romero-Severson, Ethan Molina-París, Carmen Populations and Evolution Quantitative Methods With a single circulating vector-borne virus, the basic reproduction number incorporates contributions from tick-to-tick (co-feeding), tick-to-host and host-to-tick transmission routes. With two different circulating vector-borne viral strains, resident and invasive, and under the assumption that co-feeding is the only transmission route in a tick population, the invasion reproduction number depends on whether the model system of ordinary differential equations possesses the property of neutrality. We show that a simple model, with two populations of ticks infected with one strain, resident or invasive, and one population of co-infected ticks, does not have Alizon's neutrality property. We present model alternatives that are capable of representing the invasion potential of a novel strain by including populations of ticks dually infected with the same strain. The invasion reproduction number is analysed with the next-generation method and via numerical simulations. |
| title | A story of viral co-infection, co-transmission and co-feeding in ticks: how to compute an invasion reproduction number |
| topic | Populations and Evolution Quantitative Methods |
| url | https://arxiv.org/abs/2403.15282 |